Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
In: ISSN: 0006-4971, 2015
Online
academicJournal
Zugriff:
International audience ; An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8593 CLL patients of whom 437 (5%) used the IGHV3-21 gene with 254/437 (58%) classified as subset #2. Within subset #2, immunoglobulin heavy variable (IGHV)-mutated cases predominated, whereas non–subset #2/IGHV3-21 was enriched for IGHV-unmutated cases (P = .002). Subset #2 exhibited significantly shorter time-to-first-treatment (TTFT) compared with non–subset #2/IGHV3-21 (22 vs 60 months, P = .001). No such difference was observed between non–subset #2/IGHV3-21 vs the remaining CLL with similar IGHV mutational status. In conclusion, IGHV3-21 CLL should not be axiomatically considered a homogeneous entity with adverse prognosis, given that only subset #2 emerges as uniformly aggressive, contrasting non–subset #2/IGVH3-21 patients whose prognosis depends on IGHV mutational status as the remaining CLL.
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Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
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| Autor/in / Beteiligte Person: | Baliakas, Panagiotis ; Agathangelidis, Andreas ; Hadzidimitriou, Anastasia, C ; Sutton, Lesley-Ann ; Minga, Eva ; Tsanousa, Athina ; Scarfò, Lydia ; Davis, Zadie ; Yan, Xiao-Jie ; Shanafelt, Tait ; Plevova, Karla ; Sandberg, Yorick ; Juhl Vojdeman, Fie ; Boudjogra, Myriam ; Tzenou, Tatiana ; Chatzouli, Maria ; Chu, Charles ; Veronese, Silvio ; Gardiner, Anne ; Mansouri, Larry ; Smedby, Karin Ekström ; Pedersen, Lone Bredo ; Moreno, Denis ; van Lom, Kirsten ; Giudicelli, Véronique ; Skuhrova Francova, Hana ; Nguyen-Khac, Florence ; Panagiotidis, Panagiotis ; Juliusson, Gunnar ; Angelis, Lefteris ; Anagnostopoulos, Achilles ; Lefranc, Marie-Paule ; Facco, Monica ; Trentin, Livio ; Catherwood, Mark ; Montillo, Marco ; Geisler, Christian ; Langerak, Anton ; Pospisilova, Sarka ; Chiorazzi, Nicholas ; Oscier, David ; Jelinek, Diane ; Darzentas, Nikos ; Belessi, Chrysoula ; Davi, Frederic ; Ghia, Paolo ; Rosenquist, Richard ; Stamatopoulos, Kostas ; Uppsala Universitet Uppsala ; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana) ; Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University Milan, Italie (UniSR) ; Centre for Research and Technology Hellas (CERTH) ; Aristotle University of Thessaloniki ; The Feinstein Institute for Medical Research ; Mayo Clinic Rochester ; Central European Institute of Technology Brno (CEITEC MU) ; Brno University of Technology Brno (BUT) ; Masaryk University Brno (MUNI) ; University Hospital Brno ; Erasmus University Medical Center Rotterdam (Erasmus MC) ; Copenhagen, Rigshospitalet ; Copenhagen University Hospital ; CHU Pitié-Salpêtrière AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) ; University of Athens Medical School Athens ; University of Piraeus ; Karolinska Institutet Stockholm ; Institut de génétique humaine (IGH) ; Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC) ; Université Pierre et Marie Curie - Paris 6 (UPMC) ; Skane University Hospital Lund ; General Hospital of Thessaloniki George Papanikolaou ; Università degli Studi di Padova = University of Padua (Unipd) ; Belfast City Hospital ; Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico ; "IASO" General Hospital of Athens ; University, Uppsala |
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| Zeitschrift: | ISSN: 0006-4971, 2015 |
| Veröffentlichung: | HAL CCSD ; American Society of Hematology, 2015 |
| Medientyp: | academicJournal |
| DOI: | 10.1182/blood-2014-09-600874 |
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