Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Mulligan, Anna Marie ; Couch, Fergus J ; et al.

Onkologi ; Hälsouniversitetet ; Klinisk patologi och klinisk genetik ; University of Toronto ; Rochester ; University of Cambridge ; University of Penn ; University of Southampton ; University of Helsinki ; University of So Calif ; Mem Sloan Kettering Cancer Centre ; NCI ; Queensland Institute Medical Research ; University Hospital Cologne ; Centre Hospital University of Lyon Centre Leon Berard ; Vilnius University Hospital Santariskiu Clin ; Copenhagen University Hospital ; Copenhagen University Hospital, Rigshosp ; Spanish National Cancer Research Centre ; University of Valladolid ; Hospital Clin University of Lozano Blesa ; National Centre Science Research Demokritos ; Fdn IRCCS Ist Nazl Tumouri INT ; Ist Europeo Oncol, Div Cancer Prevent and Genet ; IRCCS ; University of Turin ; University of Florence ; University of Roma La Sapienza ; Regina Elena Institute Cancer Research ; Ist Europeo Oncol ; DKFZ ; Netherlands Cancer Institute ; Vrije University of Amsterdam Medical Centre ; Leiden University ; MUMC ; Radboud University of Nijmegen ; Erasmus University ; University of Medical Centre Utrecht ; University of Amsterdam ; Queen Mary University of London ; Central Manchester University Hospital NHS Fdn Trust ; Institute Cancer Research, Oncogenet Team, London ; Guys and St Thomas NHS Fdn Trust ; Yorkshire Regional Genet Serv ; Yorkhill Hospital ; Sheffield Childrens Hospital ; St Michaels Hospital ; Kennedy Galton Centre ; NHS Grampian ; Nottingham University Hospital NHS Trust ; Liverpool Womens NHS Fdn Trust ; University Hospital Leicester NHS Trust ; Great Ormond St Hospital Sick Children ; Glan Clwyd Gen Hospital ; Singleton Hospital ; University of Kansas ; University of Leipzig ; Technical University of Munich ; University of Munich ; University of Kiel ; University of Dusseldorf ; University of Heidelberg Hospital ; University Hospital ; Hannover Medical Sch ; Technical University of Dresden ; University of Munster ; Charite, Campus Virchov Klinikum ; University of Wurzburg ; University of Regensburg ; University Hospital, Frankfurt ; Institute Cancer Research,London ; Institute Curie ; Avicenne Hospital ; University of Lyon 1 ; Centre Francois Baclesse ; CLCC Paul Strauss ; CHU Bretonneau ; CHU Amaud de Villeneuve ; Centre Hospital University of St Etienne ; University of Bordeaux ; Georgetown University ; Hospital Clin San Carlos ; Hospital Duran i Reynals Bellvitge Biomed Research Institute ID ; Landspitali University Hospital ; CHU Quebec ; Ist Oncology Veneto IOV IRCCS ; University of Padua ; Peter MacCallum Cancer Centre ; Prince Wales Hospital ; Abramson Cancer Centre ; University of Chicago ; City Hope National Medical Centre ; Creighton University ; University of Calif Los Angeles ; University of Texas SW Medical Centre Dallas ; Mayo Clin ; University of Delaware ; Amer Cancer Soc ; Medical University of Vienna ; US National Cancer Institute ; NN Petrov Institute Oncol ; Mt Sinai Hospital ; Ohio State University ; University of Copenhagen ; Odense University Hospital ; Aarhus University Hospital ; Vejle Hospital ; University of Pisa ; University of Lund Hospital ; Karolinska University Hospital ; Sahlgrens University Hospital ; University of Calif San Francisco ; Roswell Pk Cancer Institute ; Cedars Sinai Medical Centre ; Cancer Prevent Institute Calif ; Fox Chase Cancer Centre ; University of Utah ; University of Melbourne ; Columbia University ; Dana Farber Cancer Institute ; BioMed Central, 2011

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Introduction: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour. less thanbrgreater than less thanbrgreater thanMethods: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach. less thanbrgreater than less thanbrgreater thanResults: The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 x 10(-6)). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. less thanbrgreater than less thanbrgreater thanConclusions: The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying ...

Titel:	Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
Autor/in / Beteiligte Person:	Mulligan, Anna Marie ; Couch, Fergus J ; Barrowdale, Daniel ; Domchek, Susan M ; Eccles, Diana ; Nevanlinna, Heli ; Ramus, Susan J ; Robson, Mark ; Sherman, Mark ; Spurdle, Amanda B ; Wappenschmidt, Barbara ; Lee, Andrew ; McGuffog, Lesley ; Healey, Sue ; Sinilnikova, Olga M ; Janavicius, Ramunas ; Hansen, Thomas V O ; Nielsen, Finn C ; Ejlertsen, Bent ; Osorio, Ana ; Munoz-Repeto, Ivan ; Duran, Mercedes ; Godino, Javier ; Pertesi, Maroulio ; Benitez, Javier ; Peterlongo, Paolo ; Manoukian, Siranoush ; Peissel, Bernard ; Zaffaroni, Daniela ; Cattaneo, Elisa ; Bonanni, Bernardo ; Viel, Alessandra ; Pasini, Barbara ; Papi, Laura ; Ottini, Laura ; Savarese, Antonella ; Bernard, Loris ; Radice, Paolo ; Hamann, Ute ; Verheus, Martijn ; Meijers-Heijboer, Hanne E J ; Wijnen, Juul ; Gomez Garcia, EncarnaB ; Nelen, Marcel R ; Kets, C Marleen ; Seynaeve, Caroline ; Tilanus-Linthorst, Madeleine M A ; van der Luijt, Rob B ; van Os, Theo ; Rookus, Matti ; Frost, Debra ; Jones, J Louise ; Evans, D Gareth ; Lalloo, Fiona ; Eeles, Ros ; Izatt, Louise ; Adlard, Julian ; Davidson, Rosemarie ; Cook, Jackie ; Donaldson, Alan ; Dorkins, Huw ; Gregory, Helen ; Eason, Jacqueline ; Houghton, Catherine ; Barwell, Julian ; E Side, Lucy ; McCann, Emma ; Murray, Alex ; Peock, Susan ; K Godwin, Andrew ; K Schmutzler, Rita ; Rhiem, Kerstin ; Engel, Christoph ; Meindl, Alfons ; Ruehl, Ina ; Arnold, Norbert ; Niederacher, Dieter ; Sutter, Christian ; Deissler, Helmut ; Gadzicki, Dorothea ; Kast, Karin ; Preisler-Adams, Sabine ; Varon-Mateeva, Raymonda ; Schoenbuchner, Ines ; Fiebig, Britta ; Heinritz, Wolfram ; Schaefer, Dieter ; Gevensleben, Heidrun ; Caux-Moncoutier, Virginie ; Fassy-Colcombet, Marion ; Cornelis, Francois ; Mazoyer, Sylvie ; Leone, Melanie ; Boutry-Kryza, Nadia ; Hardouin, Agnes ; Berthet, Pascaline ; Muller, Daniele ; Fricker, Jean-Pierre ; Mortemousque, Isabelle ; Pujol, Pascal ; Coupier, Isabelle ; Lebrun, Marine ; Kientz, Caroline ; Longy, Michel ; Sevenet, Nicolas ; Stoppa-Lyonnet, Dominique ; Isaacs, Claudine ; Caldes, Trinidad ; de la Hoya, Miguel ; Heikkinen, Tuomas ; Aittomaki, Kristiina ; Blanco, Ignacio ; Lazaro, Conxi ; B Barkardottir, Rosa ; Soucy, Penny ; Dumont, Martine ; Simard, Jacques ; Montagna, Marco ; Tognazzo, Silvia ; DAndrea, Emma ; Fox, Stephen ; Yan, Max ; Rebbeck, Tim ; I Olopade, Olufunmilayo ; N Weitzel, Jeffrey ; T Lynch, Henry ; A Ganz, Patricia ; E Tomlinson, Gail ; Wang, Xianshu ; Fredericksen, Zachary ; S Pankratz, Vernon ; M Lindor, Noralane ; Szabo, Csilla ; Offit, Kenneth ; Sakr, Rita ; Gaudet, Mia ; Bhatia, Jasmine ; Kauff, Noah ; F Singer, Christian ; Tea, Muy-Kheng ; Gschwantler-Kaulich, Daphne ; Fink-Retter, Anneliese ; L Mai, Phuong ; H Greene, Mark ; Imyanitov, Evgeny ; P OMalley, Frances ; Ozcelik, Hilmi ; Glendon, Gordon ; Gerdes, Anne-Marie ; Thomassen, Mads ; A Kruse, Torben ; Birk Jensen, Uffe ; Skytte, Anne-Bine ; A Caligo, Maria ; Soller, Maria ; Henriksson, Karin ; Anna Wachenfeldt, von ; Arver, Brita ; Stenmark Askmalm, Marie ; Karlsson, Per ; Chun Ding, Yuan ; L Neuhausen, Susan ; Beattie, Mary ; D P Pharoah, Paul ; B Moysich, Kirsten ; L Nathanson, Katherine ; Y Karlan, Beth ; Gross, Jenny ; M John, Esther ; B Daly, Mary ; M Buys, Saundra ; C Southey, Melissa ; L Hopper, John ; Beth Terry, Mary ; Chung, Wendy ; F Miron, Alexander ; Goldgar, David ; Chenevix-Trench, Georgia ; F Easton, Douglas ; L Andrulis, Irene ; C Antoniou, Antonis
Link:	Volltext https://doi.org/10.1186/bcr3052
Veröffentlichung:	Onkologi ; Hälsouniversitetet ; Klinisk patologi och klinisk genetik ; University of Toronto ; Rochester ; University of Cambridge ; University of Penn ; University of Southampton ; University of Helsinki ; University of So Calif ; Mem Sloan Kettering Cancer Centre ; NCI ; Queensland Institute Medical Research ; University Hospital Cologne ; Centre Hospital University of Lyon Centre Leon Berard ; Vilnius University Hospital Santariskiu Clin ; Copenhagen University Hospital ; Copenhagen University Hospital, Rigshosp ; Spanish National Cancer Research Centre ; University of Valladolid ; Hospital Clin University of Lozano Blesa ; National Centre Science Research Demokritos ; Fdn IRCCS Ist Nazl Tumouri INT ; Ist Europeo Oncol, Div Cancer Prevent and Genet ; IRCCS ; University of Turin ; University of Florence ; University of Roma La Sapienza ; Regina Elena Institute Cancer Research ; Ist Europeo Oncol ; DKFZ ; Netherlands Cancer Institute ; Vrije University of Amsterdam Medical Centre ; Leiden University ; MUMC ; Radboud University of Nijmegen ; Erasmus University ; University of Medical Centre Utrecht ; University of Amsterdam ; Queen Mary University of London ; Central Manchester University Hospital NHS Fdn Trust ; Institute Cancer Research, Oncogenet Team, London ; Guys and St Thomas NHS Fdn Trust ; Yorkshire Regional Genet Serv ; Yorkhill Hospital ; Sheffield Childrens Hospital ; St Michaels Hospital ; Kennedy Galton Centre ; NHS Grampian ; Nottingham University Hospital NHS Trust ; Liverpool Womens NHS Fdn Trust ; University Hospital Leicester NHS Trust ; Great Ormond St Hospital Sick Children ; Glan Clwyd Gen Hospital ; Singleton Hospital ; University of Kansas ; University of Leipzig ; Technical University of Munich ; University of Munich ; University of Kiel ; University of Dusseldorf ; University of Heidelberg Hospital ; University Hospital ; Hannover Medical Sch ; Technical University of Dresden ; University of Munster ; Charite, Campus Virchov Klinikum ; University of Wurzburg ; University of Regensburg ; University Hospital, Frankfurt ; Institute Cancer Research,London ; Institute Curie ; Avicenne Hospital ; University of Lyon 1 ; Centre Francois Baclesse ; CLCC Paul Strauss ; CHU Bretonneau ; CHU Amaud de Villeneuve ; Centre Hospital University of St Etienne ; University of Bordeaux ; Georgetown University ; Hospital Clin San Carlos ; Hospital Duran i Reynals Bellvitge Biomed Research Institute ID ; Landspitali University Hospital ; CHU Quebec ; Ist Oncology Veneto IOV IRCCS ; University of Padua ; Peter MacCallum Cancer Centre ; Prince Wales Hospital ; Abramson Cancer Centre ; University of Chicago ; City Hope National Medical Centre ; Creighton University ; University of Calif Los Angeles ; University of Texas SW Medical Centre Dallas ; Mayo Clin ; University of Delaware ; Amer Cancer Soc ; Medical University of Vienna ; US National Cancer Institute ; NN Petrov Institute Oncol ; Mt Sinai Hospital ; Ohio State University ; University of Copenhagen ; Odense University Hospital ; Aarhus University Hospital ; Vejle Hospital ; University of Pisa ; University of Lund Hospital ; Karolinska University Hospital ; Sahlgrens University Hospital ; University of Calif San Francisco ; Roswell Pk Cancer Institute ; Cedars Sinai Medical Centre ; Cancer Prevent Institute Calif ; Fox Chase Cancer Centre ; University of Utah ; University of Melbourne ; Columbia University ; Dana Farber Cancer Institute ; BioMed Central, 2011
Medientyp:	academicJournal
DOI:	10.1186/bcr3052
Schlagwort:	Social Sciences Samhällsvetenskap
Sonstiges:	Nachgewiesen in: BASE Sprachen: English Collection: Linköping University Electronic Press (LiU E-Press) Document Type: article in journal/newspaper File Description: application/pdf Language: English Rights: info:eu-repo/semantics/openAccess

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