Imaging of CDX metastasis in Hltf- deleted mice at necropsy.
2021
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Zugriff:
Mice were anesthetized with isoflurane and metastatic CRC was detected by BLI (A) prior to necropsy. Immediately following euthanasia, mice were opened via a mid-sagittal incision and the primary CDX tumor (B1) was removed followed by lymph nodes near the stomach and spleen (B2). Metastatic sternal lymph nodes below (B3) and above (B4) the diaphragm were removed as was a peritoneal carcinomatosis (B5). Mice were imaged a second time (C) to guide removal of inguinal lymph nodes (D6) and metastatic tissue extending into the scrotum (D7). All tissues were evaluated for S-nitrosylation of human proteins.
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Imaging of CDX metastasis in Hltf- deleted mice at necropsy.
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Autor/in / Beteiligte Person: | Rebecca A. Helmer (7321256) ; Raul Martinez-Zaguilan (5485229) ; Gurvinder Kaur (301991) ; Lisa A. Smith (5485226) ; Jannette M. Dufour (5485223) ; Beverly S. Chilton (7321259) |
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Veröffentlichung: | 2021 |
Medientyp: | Bild |
DOI: | 10.1371/journal.pone.0251132.g005 |
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