The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions
In: $2, 2005, S. 2010-2019
Online
academicJournal
Zugriff:
Rok is a repressor of the transcriptional activator ComK and is therefore an important regulator of competence in Bacillus subtilis (T. T. Hoa, P. Tortosa, M. Albano, and D. Dubnau, Mol. Microbiol. 43:15-26, 2002). To address the wider role of Rok in the physiology of B. subtilis, we have used a combination of transcriptional profiling, gel shift experiments, and the analysis of lacZ fusions. We demonstrate that Rok is a repressor of a family of genes that specify membrane-localized and secreted proteins, including a number of genes that encode products with antibiotic activity. We present evidence for the recent introduction of rok into the B. subtilis-Bacillus licheniformis-Bacifflus amyloliquefaciens group by horizontal transmission.
Titel: |
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions
|
---|---|
Autor/in / Beteiligte Person: | Albano, M ; Smits, WK ; Ho, LTY ; Kraigher, B ; Mandic-Mulec, No Value ; Kuipers, OP ; Dubnau, D ; Smits, Wiep Klaas ; Ho, Linh T.Y. ; Mandic-Mulec, Ines |
Link: | |
Zeitschrift: | $2, 2005, S. 2010-2019 |
Veröffentlichung: | 2005 |
Medientyp: | academicJournal |
DOI: | 10.1128/JB.187.6.2010-2019.2005 |
Schlagwort: |
|
Sonstiges: |
|