Synthesis of 16α-amino-pregnenolone derivatives via ionic liquid-catalyzed aza-Michael addition and their evaluation as C 17,20 -lyase inhibitors
In: $2, 2017, S. 61-66
academicJournal
Zugriff:
Aza-Michael addition of 16-dehydropregnenolone was studied in the presence of a basic ionic liquid, [DBU][OAc] as catalyst and solvent. The reaction was carried out using different primary and secondary amines as N-nucleophiles. The products were obtained in moderate to good yields and were characterized by 1 H and 13 C NMR, MS and IR. The ionic liquid was found to be an efficient and recyclable catalyst that was reused five times. The products were investigated for the inhibition of in vitro C 17,20 -lyase activity and displayed moderate inhibitory effect.
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Synthesis of 16α-amino-pregnenolone derivatives via ionic liquid-catalyzed aza-Michael addition and their evaluation as C 17,20 -lyase inhibitors
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Autor/in / Beteiligte Person: | Szánti-Pintér, Eszter ; Maksó, Lilla ; Gömöry, Ágnes ; Wouters, Johan ; Edina Herman, Bianka ; Szécsi, Mihály ; Mikle, Gábor ; Kollár, László ; Skoda-Földes, Rita |
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Zeitschrift: | $2, 2017, S. 61-66 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.steroids.2017.05.006 |
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