Development of a highly sensitive fluorescent probe using Delonix regia (Gulmohar) tree pod shell for precise sarcosine detection in human urine samples: advancing prostate cancer diagnosis ...
Taylor & Francis, 2024
academicJournal
Zugriff:
We designed a highly sensitive fluorescent sensor for the early detection of sarcosine, a potential biomarker for prostate cancer. This sensor was based on surface-cobalt-doped fluorescent carbon quantum dots (Co-CD) using a FRET-based photoluminescent sensing platform. Blue luminescent carbon quantum dots (CQD) were synthesised through a hydrothermal approach, utilizing Delonix regia tree pod shells. Cobalt was employed to functionalize the CQD, enhancing the quantum-entrapped effects and minimizing surface flaws. To optimize Co-CD preparation, we employed a Box-Behnken design (BBD), and response surface methodology (RSM) based on single-factor experiments. The Co-CD was then used as a fluorescent probe for selective Cu 2+ detection, with Cu 2+ quenching Co-CD fluorescence through an energy transfer process, referred to as ‘turn-off’. When sarcosine was introduced, the fluorescence intensity of Co-CD was restored, creating a ‘turn-on’ response. The sensor exhibited a Cu 2+ detection limit (LOD) of 2.4 µM ...
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Development of a highly sensitive fluorescent probe using Delonix regia (Gulmohar) tree pod shell for precise sarcosine detection in human urine samples: advancing prostate cancer diagnosis ...
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Autor/in / Beteiligte Person: | Zeyadi, Mustafa ; Chaudhari, Komal G. ; Patil, Pravin O. ; Al-Abbasi, Fahad A. ; Almalki, Naif A. R. ; Alqurashi, May M. ; Kazmi, Imran ; Patil, Shaktipal ; Khan, Zamir G. |
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Veröffentlichung: | Taylor & Francis, 2024 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.25048160.v1 |
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