Active and passive biomonitoring suggest metabolic adaptation in blue mussels (Mytilus spp.) chronically exposed to a moderate contamination in Brest harbor (France)
In: ISSN: 0166-445X ; Aquatic Toxicology ; https://hal.science/hal-02558205 ; Aquatic Toxicology, 2015, 162, pp.126-137. ⟨10.1016/j.aquatox.2015.03.008⟩, 2015
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Zugriff:
Brest harbor (Bay of Brest, Brittany, France) has a severe past of anthropogenic chemical contamination, but inputs tended to decrease, indicating a reassessment of its ecotoxicological status should be carried out. Here, native and caged mussels (Mytilus spp.) were used in combination to evaluate biological effects of chronic chemical contamination in Brest harbor. Polycyclic aromatic hydrocarbon (PAH) contamination was measured in mussel tissues as a proxy of harbor and urban pollution. Biochemical biomarkers of xenobiotic biotransformation, antioxidant defenses, generation of reducing equivalents, energy metabolism and oxidative damage were studied in both gills and digestive glands of native and caged mussels. In particular, activities of glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), NADP-dependent isocitrate dehydrogenase (IDP), pyruvate kinase (PK) and phosphoenolpyruvate carboxykinase (PEPCK) were measured and lipid peroxidation was assessed by malondialdehyde (MDA) quantification. In addition, a condition index was calculated to assess the overall health of the mussels. Moderate PAH contamination was detected in digestive glands of both native and caged individuals from the exposed site. Modulations of biomarkers were detected in digestive glands of native harbor mussels indicating the presence of a chemical pressure. In particular, results suggested increased biotransformation (GST), antioxidant defenses (CAT), NADPH generation (IDP) and gluconeogenesis (PEPCK), which could represent a coordinated response against chemically-induced cellular stress. Lipid peroxidation assessment and condition index indicated an absence of acute stress in the same mussels suggesting metabolic changes could, at least partially, offset the negative effects of contamination. In caged mussels, only GR was found modulated compared to non-exposed mussels but significant differences in oxidative stress and energy-related biomarkers were ...
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Active and passive biomonitoring suggest metabolic adaptation in blue mussels (Mytilus spp.) chronically exposed to a moderate contamination in Brest harbor (France)
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Autor/in / Beteiligte Person: | Lacroix, Camille ; Richard, Gaëlle ; Seguineau, Catherine ; Guyomarch, Julien ; Moraga, Dario ; Auffret, Michel ; Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR) ; Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM) ; Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) ; Laboratoire de Physiologie des Invertébrés (LPI) ; Physiologie Fonctionnelle des Organismes Marins (PFOM) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) ; Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) ; Centre de documentation de recherche et d'expérimentations sur les pollutions accidentelles des eaux (Cedre) ; Cedre ; ANR-12-ISV7-0004,IPOC,Interactions entre la POllution et les Changements climatiques : développement d'une nouvelle stratégie de surveillance(2012) |
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Zeitschrift: | ISSN: 0166-445X ; Aquatic Toxicology ; https://hal.science/hal-02558205 ; Aquatic Toxicology, 2015, 162, pp.126-137. ⟨10.1016/j.aquatox.2015.03.008⟩, 2015 |
Veröffentlichung: | HAL CCSD ; Elsevier, 2015 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.aquatox.2015.03.008 |
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