Catalytic Asymmetric Conjugate Addition/Hydroalkoxylation Sequence: Expeditious Access to Enantioenriched Eight-Membered Cyclic Ether Derivatives
2021
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Zugriff:
A sequential enantioselective conjugate addition/hydroalkoxylation between in situ generated ortho -quinomethanes and ynones by combining bifunctional squaramide and DBU catalysis has been developed. A variety of eight-membered cyclic ethers with two contiguous tertiary stereocenters were obtained in high yields with excellent stereoselectivities. This reaction not only provides a new strategy for constructing enantioenriched eight-membered cyclic ethers but also demonstrates the practicability of ynones as C4-syntons for the synthesis of chiral medium-membered rings.
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Catalytic Asymmetric Conjugate Addition/Hydroalkoxylation Sequence: Expeditious Access to Enantioenriched Eight-Membered Cyclic Ether Derivatives
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Autor/in / Beteiligte Person: | Suo-Suo Qi (9186543) ; Hao Yin (381910) ; Yi-Feng Wang (529972) ; Chao-Jie Wang (6916778) ; Hong-Te Han (10324573) ; Tong-Tong Man (10324576) ; Dan-Qian Xu (1607977) |
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Veröffentlichung: | 2021 |
Medientyp: | unknown |
DOI: | 10.1021/acs.orglett.1c00392.s001 |
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