AC invasion is disrupted in temperature sensitive SWI/SNF hypomorphs.
2022
academicJournal
Zugriff:
Single planes of confocal z-stacks representing AC invasion in swsn-1(os22) and swsn-4(os13) temperature sensitive mutants with fluorescently labeled AC (magenta, cdh-3>mCherry :: moeABD ) and BM (green, laminin :: GFP ) scored at the permissive temperature (A) and restrictive temperature (B) . Significant loss of invasion was seen in both swsn-1(os22) (20% loss of invasion) and swsn-4(os13) (24% loss of invasion) hypomorphic ts strains when grown at the restrictive temperature 25°C and assessed at the P6.p 4-cell 1° VPC stage (B) . White arrowheads indicate ACs. Yellow arrowheads in A indicate boundaries of breaches in the BM. Numbers in bottom right of fluorescence overlay panel in A indicate penetrance of wildtype AC invasion. Numbers in bottom right of fluorescence overlay panel in B indicate penetrance of invasion defects. (PDF)
Titel: |
AC invasion is disrupted in temperature sensitive SWI/SNF hypomorphs.
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Autor/in / Beteiligte Person: | Jayson J. Smith (11902332) ; Yutong Xiao (11902335) ; Nithin Parsan (11902338) ; Taylor N. Medwig-Kinney (11902341) ; Michael A. Q. Martinez (11902344) ; Frances E. Q. Moore (11902347) ; Nicholas J. Palmisano (9975421) ; Abraham Q. Kohrman (11902350) ; Mana Chandhok Delos Reyes (11902353) ; Rebecca C. Adikes (11902356) ; Simeiyun Liu (11902359) ; Sydney A. Bracht (11902362) ; Wan Zhang (477556) ; Kailong Wen (6245135) ; Paschalis Kratsios (6245147) ; David Q. Matus (7866471) |
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Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
DOI: | 10.1371/journal.pgen.1009981.s001 |
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