Prevalence of obstructive sleep apnoea syndrome following oropharyngeal cancer treatment: A prospective cohort study
In: ISSN: 0307-7772, 2017
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Zugriff:
International audience ; Objectives: To evaluate the prevalence of obstructive sleep apnoea syndrome (OSAS) in a population of patients treated for an advanced oropharyngeal cancer (AJCC Stage III or IV), depending on treatment strategy, and to evaluate its impact on quality of life.Design: Prospective cohort study.Setting: University Teaching Hospital of La Conception, Marseille, France.Participants: Fifty-one disease-free patients were included. Forty-one patients received a combined chemoradiotherapy, while 10 patients were treated by surgery followed by chemoradiotherapy.Main outcome measures: Every patient underwent a formal sleep consultation and was asked to complete the Epworth Sleepiness Scale and EORTC QLQ C-30 and the EORTC H&N 35 questionnaires. A home overnight respiratory polygraphy was performed in every subject.Results: The mean time between the end of cancer treatment and the OSAS analysis was 54.04 months [20; 84]. An OSAS was found in 25.49% of our patients. There was no significant difference between patients treated with either surgery (30%) or CRT (24.39%), P=.79. The EORTC QLQ C-30 questionnaire showed a significant difference between positive and negative OSAS groups in the Global Health Status Scale (50.64 vs 67.11, P=.02) and in the fatigue item (35.04 vs 17.25, P=.03).Conclusions: Our population with advanced oropharyngeal cancer, whatever the treatment strategy it may be, was at risk of developing OSAS with negative impact on quality of life. A routine screening and treatment of OSAS seems necessary to improve the quality of life of patients treated for advanced oropharyngeal cancer.
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Prevalence of obstructive sleep apnoea syndrome following oropharyngeal cancer treatment: A prospective cohort study
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Autor/in / Beteiligte Person: | Loth, A ; Michel, J ; Giorgi, R ; Santini, L ; Rey, M ; Elbaum, J-M ; Roux, N ; Giovanni, A ; Dessi, P ; Fakhry, N ; Hôpital de la Conception CHU - APHM (LA CONCEPTION) ; Aix Marseille Université (AMU) ; Hôpital de la Timone CHU - APHM (TIMONE) ; Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD) ; Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Laboratoire Parole et Langage (LPL) ; Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
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Zeitschrift: | ISSN: 0307-7772, 2017 |
Veröffentlichung: | HAL CCSD ; Wiley-Blackwell, 2017 |
Medientyp: | academicJournal |
DOI: | 10.1111/coa.12869 |
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