Recovery of activity over time.
2021
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Zugriff:
(Mean firing rates of neurons are calculated over a 2500 ms window and plotted in 100 ms increments.). (A) shows the firing rates of the whole excitatory population at t = {1500 s, 2001.5 s, 4000 s, and 18,000 s}. These are marked by dashed lines in the next graphs. The LPZ is indicated by white circles here and in following figures. (B) shows mean firing rate of neurons in LPZ-C; (C) shows mean firing rate of neurons in peri-LPZ; The network is permitted to achieve its balanced Asynchronous Irregular (AI) low frequency firing regime under the action of inhibitory synaptic plasticity ( t ≤ 1500 s). Structural plasticity is then activated at all neurites—pre-synaptic and post-synaptic, excitatory and inhibitory—to confirm that the network remains in its balanced AI state (panel 1 in A). At ( t = 2000 s), neurons in the LPZ are deafferented (panel 2 in A is at t = 2001.5 s) and the network allowed to repair itself under the action of our structural plasticity mechanism (panels 3 ( t = 4000 s) and 4 ( t = 18,000 s) in A).
Titel: |
Recovery of activity over time.
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Autor/in / Beteiligte Person: | Ankur Sinha (10906249) ; Christoph Metzner (10906252) ; Neil Davey (10906255) ; Roderick Adams (10906258) ; Michael Schmuker (17095) ; Volker Steuber (8909966) |
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Veröffentlichung: | 2021 |
Medientyp: | Bild |
DOI: | 10.1371/journal.pcbi.1008996.g003 |
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