Latency of Herpes simplex virus type-1 in human geniculate and vestibular ganglia is associated with infiltration of CD8+ T-cells
In: ISSN: 0146-6615, 2010
Online
academicJournal
Zugriff:
International audience ; Herpes simplex virus type-1 latency and CD8+ T-cell occurence were investigated in the trigeminal, geniculate, and vestibular ganglia from seven deceased humans. The HSV-1 ''latency-associated transcript'' was assessed by in situ-hybridization and quantitative RT-PCR. Infiltration of CD8+ T-cell was detected by immunohistochemistry and quantitative RT-PCR. The data show that HSV-1 latency and CD8+ T-cell infiltration are not solely confined to the trigeminal ganglia but can also occur in other cranial ganglia along the neuroaxis. However, the HSV-1 latency transcripts in the geniculate and vestibular ganglia were expressed at a very low level. The difference in CD8 transcript levels among HSV-1 latently infected trigeminal ganglia, geniculate, and vestibular ganglia was less conspicuous. Colocalisation of latent HSV-1 and CD8+ T-cells in geniculate and vestibular ganglia supports further the hypothesis that HSV-1 reactivation is possible in these ganglia and is the cause of Bell's palsy and vestibular neuritis.
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Latency of Herpes simplex virus type-1 in human geniculate and vestibular ganglia is associated with infiltration of CD8+ T-cells
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Autor/in / Beteiligte Person: | Theil, Diethilde ; Klinikum der Universitat Munchen ; Ludwig-Maximilians-Universität München (LMU) |
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Zeitschrift: | ISSN: 0146-6615, 2010 |
Veröffentlichung: | HAL CCSD ; Wiley-Blackwell, 2010 |
Medientyp: | academicJournal |
DOI: | 10.1002/jmv.21904 |
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