Highly regioselective synthesis of lactams via cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst
In: RSC Adv, 2023
academicJournal
Zugriff:
Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams via DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to good yields (32 examples). The control experiments revealed that the hydrogen of the amide was the key factor.
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Highly regioselective synthesis of lactams via cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst
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Autor/in / Beteiligte Person: | Qin, Xin ; Zhang, Jinhai ; Wang, Zhan-Yong ; Song, Yimei ; Yang, Yixiao ; Zhang, Wenhai ; Liu, Hongxin |
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Zeitschrift: | RSC Adv, 2023 |
Veröffentlichung: | The Royal Society of Chemistry, 2023 |
Medientyp: | academicJournal |
DOI: | 10.1039/d2ra07117g |
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