Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model
In: Life, Vol 10, Iss 161, p 161 (2020, Jg. 10 (2020), Heft 161, p 161
Online
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Zugriff:
The Microdosimetric Kinetic Model (MKM) to predict the effects of ionizing radiation on cell colonies is studied and reformulated for the case of high-linear energy transfer (LET) radiations with a low dose. When the number of radiation events happening in a subnuclear domain follows a Poisson distribution, the MKM predicts a linear-quadratic (LQ) survival curve. We show that when few events occur, as for high-LET radiations at doses lower than the mean specific energy imparted to the nucleus, z F , n , a Poisson distribution can no longer be assumed and an initial pure linear relationship between dose and survival fraction should be observed. Predictions of survival curves for combinations of high-LET and low-LET radiations are produced under two assumptions for their comparison: independent and combined action. Survival curves from previously published articles of V79 cell colonies exposed to X-rays, α particles, Ar-ions, Fe-ions, Ne-ions and mixtures of X-rays and each one of the ions are predicted according to the modified MKM. We conclude that mixtures of high-LET and low-LET radiations may enhance the effect of individual actions due to the increase of events in domains provided by the low-LET radiation. This hypothesis is only partially validated by the analyzed experiments.
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Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model
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Autor/in / Beteiligte Person: | Bertolet, Alejandro ; Carabe, Alejandro |
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Zeitschrift: | Life, Vol 10, Iss 161, p 161 (2020, Jg. 10 (2020), Heft 161, p 161 |
Veröffentlichung: | MDPI AG, 2020 |
Medientyp: | academicJournal |
ISSN: | 2075-1729 (print) |
DOI: | 10.3390/life10090161 |
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