The decay of E-LTP is determined by the size of spine and PSD.
2021
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Zugriff:
(A) In the cooperative model (blue line), the number of bound AMPARs in the fixed point B * strongly depends on the amount of exocytosis from REs ( S exo ) compared to the basic model (black line). Thereby, small changes in the amount of exocytosed AMPARs Δ S exo are sufficient for LTP expression (Δ B ). (B) The decay time and relative amplitude of LTP change with the size of the PSD P . Whereas bound AMPARs B show fast dynamics for small PSDs (dark blue line), B only slowly decays back to the steady state baseline for large PSDs (light blue line). (C) E-LTP for different spine sizes where the PSD area scales linear with the spine surface area ( P ∝ A spine ) but the amount of baseline AMPAR exocytosis is kept constant (). Top: Although large spines lack pronounces sLTP, the slower dynamics due to the larger PSD result in E-LTP with a time scale similar to that of smaller spines. Bottom: The change in AMPAR abundance at the PSD 1 and 20 min. after LTP induction. (D) Same as in (C) but depends on the initial spine volume according to Eq (13) . Top: E-LTP decays rapidly for large and very small spines. Bottom: Same as in (C) .
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The decay of E-LTP is determined by the size of spine and PSD.
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Autor/in / Beteiligte Person: | Moritz F. P. Becker (10344984) ; Christian Tetzlaff (235968) |
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Veröffentlichung: | 2021 |
Medientyp: | Bild |
DOI: | 10.1371/journal.pcbi.1008813.g005 |
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