Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics
BMJ Publishing Group, 2023
academicJournal
Zugriff:
Objective: To implement complex, PINCER (pharmacist led information technology intervention) prescribing indicators, on a national scale with general practice data to describe the impact of the covid-19 pandemic on safe prescribing.Design: Population based, retrospective cohort study using federated analytics.Setting: Electronic general practice health record data from 56.8 million NHS patients by use of the OpenSAFELY platform, with the approval of the National Health Service (NHS) England.Participants: NHS patients (aged 18-120 years) who were alive and registered at a general practice that used TPP or EMIS computer systems and were recorded as at risk of at least one potentially hazardous PINCER indicator.Main outcome measure: Between 1 September 2019 and 1 September 2021, monthly trends and between practice variation for compliance with 13 PINCER indicators, as calculated on the first of every month, were reported. Prescriptions that do not adhere to these indicators are potentially hazardous and can cause gastrointestinal bleeds; are cautioned against in specific conditions (specifically heart failure, asthma, and chronic renal failure); or require blood test monitoring. The percentage for each indicator is formed of a numerator of patients deemed to be at risk of a potentially hazardous prescribing event and the denominator is of patients for which assessment of the indicator is clinically meaningful. Higher indicator percentages represent potentially poorer performance on medication safety.Results: The PINCER indicators were successfully implemented across general practice data for 56.8 million patient records from 6367 practices in OpenSAFELY. Hazardous prescribing remained largely unchanged during the covid-19 pandemic, with no evidence of increases in indicators of harm as captured by the PINCER indicators. The percentage of patients at risk of potentially hazardous prescribing, as defined by each PINCER indicator, at mean quarter 1 (Q1) 2020 (representing before the pandemic) ranged from 1.11% (age ...
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Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics
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Autor/in / Beteiligte Person: | Fisher, Louis ; Hopcroft, Lisa EM ; Rodgers, Sarah ; Barrett, James ; Oliver, Kerry ; Avery, Anthony J ; Evans, Dai ; Curtis, Helen ; Croker, Richard ; Macdonald, Orla ; Morley, Jessica ; Mehrkar, Amir ; Bacon, Sebastian ; Davy, Simon ; Dillingham, Iain ; Evans, David ; Hickman, George ; Inglesby, Peter ; Morton, Caroline E ; Smith, Becky ; Ward, Tom ; Hulme, William ; Green, Amelia ; Massey, Jon ; Walker, Alex J ; Bates, Christopher ; Cockburn, Jonathan ; Parry, John ; Hester, Frank ; Harper, Sam ; O’Hanlon, Shaun ; Eavis, Alex ; Jarvis, Richard ; Avramov, Dima ; Griffiths, Paul ; Fowles, Aaron ; Parkes, Nasreen ; Goldacre, Ben ; MacKenna, Brian |
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Veröffentlichung: | BMJ Publishing Group, 2023 |
Medientyp: | academicJournal |
DOI: | 10.1136/bmjmed-2022-000392 |
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