Predictors of negative first SARS-CoV-2 RT-PCR despite final diagnosis of COVID-19 and association with outcome
In: ISSN: 2045-2322, 2021
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Zugriff:
International audience ; Abstract Reverse transcriptase-polymerase chain reaction (RT-PCR) testing is an important tool for diagnosing coronavirus disease 2019 (COVID-19). However, performance concerns have emerged recently, notably regarding sensitivity. We hypothesized that the clinical, biological, and radiological characteristics of patients with a false-negative first RT-PCR test and a final diagnosis of COVID-19 might differ from those of patients with a positive first RT-PCR test. We conducted a multicenter matched case–control study in COVID-19 patients. Patients with a negative first RT-PCR test were matched to patients with a positive first RT-PCR test on age, sex, and initial admission unit (ward or intensive care). We included 80 cases and 80 controls between March 30, and June 22, 2020. Neither mortality at hospital discharge nor hospital stay length differed between the two groups ( P = 0.80 and P = 0.54, respectively). By multivariate analysis, two factors were independently associated with a lower risk of a first false-negative test, namely, headache (adjusted OR [aOR], 0.07; 95% confidence interval [95% CI], 0.01–0.49]; P = 0.007) and fatigue/malaise (aOR, 0.16; 95% CI, 0.03–0.81; P = 0.027); two other factors were independently associated with a higher risk of a first false-negative test, namely, platelets > 207·10 3 mm −3 (aOR, 3.81; 95% CI, 1.10–13.16]; P = 0.034) and C-reactive protein > 79.8 mg·L −1 (aOR, 4.00; 95% CI, 1.21–13.19; P = 0.023). Patients with suspected COVID-19 whose laboratory tests indicating marked inflammation were at higher risk of a first false-negative RT-PCR test. Strategies involving serial RT-PCR testing must be rigorously evaluated.
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Predictors of negative first SARS-CoV-2 RT-PCR despite final diagnosis of COVID-19 and association with outcome
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Autor/in / Beteiligte Person: | Lascarrou, Jean-Baptiste ; Colin, Gwenhael ; Le Thuaut, Aurélie ; Serck, Nicolas ; Ohana, Mickael ; Sauneuf, Bertrand ; Geri, Guillaume ; Mesland, Jean-Baptiste ; Ribeyre, Gaetane ; Hussenet, Claire ; Boureau, Anne Sophie ; Gille, Thomas ; Réseau CRICS-TRIGGERSEP CHRU Tours (F-CRIN research network) ; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours) ; Hôtel-Dieu de Nantes ; Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée) ; Plateforme de Méthodologie et Biostatistique, Direction de la Recherche CHU Nantes ; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes) ; Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg) ; Les Hôpitaux Universitaires de Strasbourg (HUS) ; Service de Réanimation Polyvalente CHPC - Site Louis Pasteur ; Site Louis Pasteur, CHPC ; CH Centre Hospitalier Public du Cotentin (CHPC)-CH Centre Hospitalier Public du Cotentin (CHPC) ; Hôpital Ambroise Paré AP-HP ; Hopital de Jolimont ; Nouvelles Cliniques Nantaises - NCN Nantes ; Service de pneumologie Avicenne ; Hôpital Avicenne AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Sorbonne Paris Nord |
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Zeitschrift: | ISSN: 2045-2322, 2021 |
Veröffentlichung: | HAL CCSD ; Nature Publishing Group, 2021 |
Medientyp: | academicJournal |
DOI: | 10.1038/s41598-021-82192-6 |
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