The Notch1 activation decrease MAF cell viability and proliferation.
2021
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Zugriff:
A. Top : overexpression of N1 IC in N1 IC -GFP/MAF detected by immunoblot. increased Hes-1 expression demonstrates that the Notch pathway is activated. β-actin was used as loading control. Bottom : high intracellular Notch1 activity inhibits MAF proliferation in vitro as determined by WST cell proliferation assay. B. High activity of the intracellular Notch1 pathway decreases MAF cell viability. Top : images of cells in co-staining assay. Dead cells were double-positive [TUNEL (Red) + and active caspase-3 (Blue) + ], indicating that they are apoptotic cells. A single scale bar in a panel of pictures is representative for all pictures. Bottom : % of live cells. All data are presented as mean ± SD based on three independent experiments.
Titel: |
The Notch1 activation decrease MAF cell viability and proliferation.
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Autor/in / Beteiligte Person: | Hongwei Shao (493627) ; Mecker Moller (10291640) ; Long Cai (3080586) ; Rochelle Prokupets (10291643) ; Cuixia Yang (542545) ; Connor Costa (10291646) ; Kerstin Yu (10291649) ; Nga Le (1488691) ; Zhao-Jun Liu (168517) |
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Veröffentlichung: | 2021 |
Medientyp: | Bild |
DOI: | 10.1371/journal.pone.0248260.g003 |
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