Alterations in HIV-1 LTR promoter activity during AIDS progression
In: Virology ; 317 ; 1 ; 109-18, 2022
Online
academicJournal
Zugriff:
HIV-1 variants evolving in AIDS patients frequently show increased replicative capacity compared to those present during early asymptomatic infection. It is known that late stage HIV-1 variants often show an expanded coreceptor tropism and altered Nef function. In the present study we investigated whether enhanced HIV-1 LTR promoter activity might also evolve during disease progression. Our results demonstrate increased LTR promoter activity after AIDS progression in 3 of 12 HIV-1-infected individuals studied. Further analysis revealed that multiple alterations in the U3 core-enhancer and in the transactivation-response (TAR) region seem to be responsible for the enhanced functional activity. Our findings show that in a subset of HIV-1-infected individuals enhanced LTR transcription contributes to the increased replicative potential of late stage virus isolates and might accelerate disease progression.
Titel: |
Alterations in HIV-1 LTR promoter activity during AIDS progression
|
---|---|
Autor/in / Beteiligte Person: | Hiebenthal-Millow, Kirsten ; Greenough, Thomas C. ; Bretttler, Doreen B. ; Schindler, Michael ; Wildum, Steffen ; Sullivan, John L. ; Kirchhoff, Frank ; Program in Molecular Medicine ; Department of Pediatrics |
Link: | |
Zeitschrift: | Virology ; 317 ; 1 ; 109-18, 2022 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.virol.2003.08.034 |
Schlagwort: |
|
Sonstiges: |
|