Temperature-sensitive heparin-modified poloxamer hydrogel with affinity to KGF facilitate the morphologic and functional recovery of the injured rat uterus ...
Taylor & Francis, 2017
academicJournal
Zugriff:
Endometrial injury usually results in intrauterine adhesion (IUA), which is an important cause of infertility and recurrent miscarriage in reproductive women. There is still lack of an effective therapeutic strategy to prevent occurrence of IUA. Keratinocyte growth factor (KGF) is a potent repair factor for epithelial tissues. Here, a temperature-sensitive heparin-modified poloxamer (HP) hydrogel with affinity to KGF (KGF-HP) was used as a support matrix to prevent IUA and deliver KGF. The rheology of KGF-HP hydrogel was carefully characterized. The cold KGF-HP solution was rapidly transited to hydrogel with suitable storage modulus (G′) and loss modulus (G″) for the applications of uterus cavity at temperature of 33 °C. In vitro release demonstrated that KGF was released from HP hydrogels in sustained release manner for a long time. In vivo bioluminescence imaging showed that KGF-HP hydrogel was able to prolong the retention of the encapsulated KGF in injured uterus of rat model. Moreover, the morphology ...
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Temperature-sensitive heparin-modified poloxamer hydrogel with affinity to KGF facilitate the morphologic and functional recovery of the injured rat uterus ...
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Autor/in / Beteiligte Person: | Xu, He-Lin ; Xu, Jie ; Zhang, Si-Si ; Zhu, Qun-Yan ; Jin, Bing-Hui ; ZhuGe, De-Li ; Shen, Bi-Xin ; Wu, Xue-Qing ; Xiao, Jian ; Zhao, Ying-Zheng |
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Veröffentlichung: | Taylor & Francis, 2017 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.5067457.v1 |
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