Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
In: Archiv Der Pharmazie; Archiv Der Pharmazie. Berlin: Wiley-v C H Verlag Gmbh, v. 334, n. 6, p. 189-193, 2001.; WOS:000169717500002;; (2014) S. 189-193
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Zugriff:
With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium Il(tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.
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Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
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Autor/in / Beteiligte Person: | Silva, M. ; Lara, A. S. ; Leite, CQF ; Ferreira, E. I. ; Universidade Estadual Paulista (UNESP) |
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Quelle: | Archiv Der Pharmazie; Archiv Der Pharmazie. Berlin: Wiley-v C H Verlag Gmbh, v. 334, n. 6, p. 189-193, 2001.; WOS:000169717500002;; (2014) S. 189-193 |
Veröffentlichung: | Wiley-Blackwell, 2014 |
Medientyp: | unknown |
ISSN: | 0365-6233 (print) |
DOI: | 10.1002/1521-4184(200106)334:6 |
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