Strontium-driven physiological to pathological transition of bone-like architecture: A dose-dependent investigation
In: ISSN: 1742-7061 ; Acta Biomaterialia ; https://hal.sorbonne-universite.fr/hal-04189351 ; Acta Biomaterialia, In press, ⟨10.1016/j.actbio.2023.07.043⟩, 2023
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International audience ; Whilst strontium (Sr 2 +) is widely investigated for treating osteoporosis, it is also related to mineralization disorders such as rickets and osteomalacia. In order to clarify the physiological and pathological effects of Sr 2 + on bone biomineralization , we performed a dose-dependent investigation in bone components using a 3D scaffold that displays the hallmark features of bone tissue in terms of composition (osteoblast, collagen, carbonated apatite) and architecture (mineralized collagen fibrils hierarchically assembled into a twisted plywood geometry). As the level of Sr 2 + is increased from physiological-like to excess, both the mineral and the collagen fibrils assembly are destabilized, leading to a drop in the Young modulus, with strong implications on pre-osteoblastic cell proliferation. Furthermore, the microstructural and mechanical changes reported here correlate with that observed in bone-weakening disorders induced by Sr 2 + accumulation, which may clarify the paradoxical effects of Sr 2 + in bone mineralization. More generally, our results provide physicochemical insights into the possible effects of inorganic ions on the assembly of bone extracellular matrix and may contribute to the design of safer therapies for treating osteoporosis.
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Strontium-driven physiological to pathological transition of bone-like architecture: A dose-dependent investigation
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Autor/in / Beteiligte Person: | Bussola Tovani, Camila ; Divoux, Thibaut ; Manneville, Sébastien ; Azaïs, Thierry ; Laurent, Guillaume, P. ; de Frutos, Marta ; Gloter, Alexandre ; Ciancaglini, Pietro ; Ramos, Ana, P ; Nassif, Nadine ; Matériaux Hybrides et Procédés (LCMCP-MHP ) ; Matériaux Hybrides et Nanomatériaux (LCMCP-MHN) ; Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP) ; Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP) ; Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ; Departamento de Química Ribeirão Preto ; Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto ; Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP) ; Laboratoire de Physique de l'ENS Lyon (Phys-ENS) ; École normale supérieure de Lyon (ENS de Lyon)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS) ; Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (LCMCP-SMiLES) ; Laboratoire de Physique des Solides (LPS) ; Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
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Zeitschrift: | ISSN: 1742-7061 ; Acta Biomaterialia ; https://hal.sorbonne-universite.fr/hal-04189351 ; Acta Biomaterialia, In press, ⟨10.1016/j.actbio.2023.07.043⟩, 2023 |
Veröffentlichung: | HAL CCSD ; Elsevier, 2023 |
Medientyp: | academicJournal |
DOI: | 10.1016/j.actbio.2023.07.043 |
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