Structural insight into the role of the PAS domain for signal transduction in sensor-kinase BvgS
In: ISSN: 0021-9193, 2021
Online
academicJournal
Zugriff:
International audience ; The two-component system BvgAS controls the virulence regulon in Bordetella pertussis. BvgS is the prototype of a family of sensor histidine-kinases harboring periplasmic Venus flytrap (VFT) domains. The VFT domains are connected to the cytoplasmic kinase moiety by helical linkers separated by a Per-ARNT-Sim (PAS) domain. Antagonism between the two linkers, as one forms a coiled coil when the other is dynamic and vice versa, regulates BvgS activity. Here we solved the structure of the intervening PAS domain by X-ray
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Structural insight into the role of the PAS domain for signal transduction in sensor-kinase BvgS
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| Autor/in / Beteiligte Person: | Dupré, Elian ; Clantin, Bernard ; Yuan, Youhua ; Lecher, Sophie ; Lesne, Elodie ; Antoine, Rudy ; Villeret, Vincent ; Jacob-Dubuisson, Françoise ; Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL) ; Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire Lille (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille ; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) |
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| Zeitschrift: | ISSN: 0021-9193, 2021 |
| Veröffentlichung: | HAL CCSD ; American Society for Microbiology, 2021 |
| Medientyp: | academicJournal |
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