The Depside Derivative Pericodepside Inhibits Cancer Cell Metastasis and Proliferation by Suppressing Epithelial–Mesenchymal Transition
2024
academicJournal
Zugriff:
A depside derivative, named pericodepside ( 2 ), along with the known depside proatranorin III ( 1 ), was isolated from the solid cultivation of an Ascochyta rabiei strain that heterologously expresses atr1 and atr2 that are involved in the biosynthesis of atranorin in a fruticose lichen, Stereocaulon alpinum. The structure of 2 was determined by 1D and 2D NMR and MS spectroscopic data. The structure of 2 consisted of a depside–pericosine conjugate, with the depside moiety being identical to that found in 1 , suggesting that 1 acted as an intermediate during the formation of 2 through the esterification process. Pericodepside ( 2 ) strongly suppressed cell invasion and proliferation by inhibiting epithelial–mesenchymal transition and the transcriptional activities of β-catenin, STAT, and NF-κB in U87 (glioma cancer), MCF-7 (breast cancer), and PC3 (prostate cancer) cell lines.
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The Depside Derivative Pericodepside Inhibits Cancer Cell Metastasis and Proliferation by Suppressing Epithelial–Mesenchymal Transition
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Autor/in / Beteiligte Person: | Zhou, Rui ; Liu, Rundong ; Kyo Bin Kang ; Kim, Wonyong ; Hur, Jae-Seoun ; Kim, Hangun |
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Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
DOI: | 10.1021/acsomega.3c08136.s001 |
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