II.1 Haemodialysis dose quantification: small solutes
Oxford University Press, 2002
academicJournal
Zugriff:
Guideline II.1.1 A. Urea is the most suitable marker for the uraemic toxins in the range of the low MW solutes. ( Evidence level: B ) Guideline II.1.2 A. HD dose should be expressed in terms of equilibrated Kt/V (eKt/V) with the rate equation based on the regional blood flow two‐pool urea kinetic model [41]: eKt/V=spKt/V–(0.6×spKt/V/T)+0.03 ( with an arteriovenous access ) eKt/V=spKt/V−(0.47×spKt/V/T)+0.02 (with a venovenous access, i.e. absence of cardiopulmonary recirculation). ( Evidence level: B ) C. The value for the single‐pool Kt/V (spKt/V) should be derived from the formal single‐pool variable volume urea kinetic model (spUKM) [42]. As an alternative, the natural logarithm equation provides the most accurate estimate of spKt/V [43]: spKt/V=−ln (Ct/Co–0.008×T) +(4–3.5×Ct/Co)×dBW/BW where: K=dialyzer clearance (ml/min); V=urea distribution volume (ml); t, T=treatment time (in minutes and hours, respectively); Co, Ct=start and end‐session urea (or BUN) concentration; dBW=intradialytic weight loss (kg); BW=end‐session body weight (kg). D. Sampling Ct 30 min after the end of the session and applying the spKt/V equation gives the eKt/V value [44] (see also Guideline II.4.1). Guideline II.1.3 A. Based on the available evidence the minimum prescribed HD dose per session for a thrice‐weekly schedule should be: urea eKt/V≥1.20 (sp Kt/V∼1.4). Twice‐weekly schedules are not recommended. ( Evidence level: B )
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II.1 Haemodialysis dose quantification: small solutes
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Veröffentlichung: | Oxford University Press, 2002 |
Medientyp: | academicJournal |
DOI: | 10.1093/ndt/17.suppl_7.17 |
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