Highly Efficient Messenger RNA Transfection of Hard-to-Transfect Cells using Carbon Nanodots
In: ACS Omega, 2023
academicJournal
Zugriff:
[Image: see text] Although messenger RNA (mRNA)-based therapeutics opened up new avenues for treating various diseases, intracellular delivery of mRNA is still challenging, especially to hard-to-transfect cells. For successful mRNA therapy, the development of a delivery vehicle that can effectively transport mRNA into cells is essential. In this study, we synthesized carbon nanodots (CNDs) as an efficient mRNA delivery vehicle via a one-step microwave-assisted method. CNDs easily formed complexes with mRNA molecules by electrostatic interactions, and the gene delivery performance of CNDs was highly effective in hard-to-transfect cells. Considering their outstanding transfection ability, CNDs are expected to be further applied for mRNA-based cellular engineering.
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Highly Efficient Messenger RNA Transfection of Hard-to-Transfect Cells using Carbon Nanodots
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Autor/in / Beteiligte Person: | Shin, Hojeong ; Min, Dal-Hee |
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Zeitschrift: | ACS Omega, 2023 |
Veröffentlichung: | American Chemical Society, 2023 |
Medientyp: | academicJournal |
DOI: | 10.1021/acsomega.3c01394 |
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