How Traumatic Brain Injury History Relates to Brain Health MRI Markers and Dementia Risk: Findings from the 3C Dijon Cohort
In: ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.science/hal-04000092 ; Journal of Alzheimer's Disease, 2023, 2023
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academicJournal
Zugriff:
International audience ; BACKGROUND: The long-term effects of traumatic brain injury (TBI) with loss of consciousness (LOC) on magnetic resonance imaging (MRI) markers of brain health and on dementia risk are still debated. OBJECTIVE: To investigate the associations of history of TBI with LOC with incident dementia and neuroimaging markers of brain structure and small vessel disease lesions. METHODS: The analytical sample consisted in 4,144 participants aged 65 and older who were dementia-free at baseline from the Three City -Dijon study. History of TBI with LOC was self-reported at baseline. Clinical Dementia was assessed every two to three years, up to 12 years of follow-up. A subsample of 1,675 participants <80 years old underwent a brain MRI at baseline. We investigated the associations between history of TBI with LOC and 1) incident all cause and Alzheimer's disease (AD) dementia using illness-death models, and 2) neuroimaging markers at baseline. RESULTS: At baseline, 8.3% of the participants reported a history of TBI with LOC. In fully-adjusted models, participants with a history of TBI with LOC had no statistically significant differences in dementia risk (HR = 0.90, 95% CI = 0.60-1.36) or AD risk (HR = 1.03, 95% CI = 0.69-1.52), compared to participants without TBI history. History of TBI with LOC was associated with lower white matter volume (β= -4.58, p = 0.048), but not with other brain volumes, white matter hyperintensities volume, nor covert brain infarct. CONCLUSION: This study did not find evidence of an association between history of TBI with LOC and dementia or AD dementia risks over 12-year follow-up, brain atrophy, or markers of small vessel disease.
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How Traumatic Brain Injury History Relates to Brain Health MRI Markers and Dementia Risk: Findings from the 3C Dijon Cohort
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Autor/in / Beteiligte Person: | Grasset, Leslie ; Power, Melinda C. ; Crivello, Fabrice ; Tzourio, Christophe ; Chene, Genevieve ; Dufouil, Carole ; Bordeaux population health (BPH) ; Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Bordeaux, CIC ; Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM) ; The George Washington University (GW) ; Institut des Maladies Neurodégénératives Bordeaux (IMN) ; Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS) ; CHU Bordeaux Bordeaux ; Institut National de la Santé et de la Recherche Médicale ; Université de Bordeaux ; Fondation pour la Recherche Médicale ; Fondation Plan Alzheimer ; Mutuelle Générale de l'Education Nationale ; Conseil Régional Aquitaine ; Conseil régional de Bourgogne-Franche-Comté ; Fondation de France ; Caisse nationale de solidarité pour l'autonomie |
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Zeitschrift: | ISSN: 1387-2877 ; Journal of Alzheimer's Disease ; https://hal.science/hal-04000092 ; Journal of Alzheimer's Disease, 2023, 2023 |
Veröffentlichung: | HAL CCSD ; IOS Press, 2023 |
Medientyp: | academicJournal |
DOI: | 10.3233/JAD-220658 |
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