Παράγοντες του στρώματος του όγκου και αποπτωτικά μόρια στον γαστρικό καρκίνο ; Tumor stroma factors and apoptotic molecules in gastric cancer
National and Kapodistrian University of Athens ; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ), 2019
Online
Hochschulschrift
Zugriff:
Background : Caspase-8 and caspase-9 (CASP9) are protease enzymes that play essential roles in regulating apoptosis. Stromal-cell derived factor-1 (SDF-1), a CXC chemokine, is important for growth, angiogenesis and metastasis of tumor cells. Survivin is a member of the inhibitor of apoptosis family of proteins. E-selectin is an adhesion molecule expressed on activated endothelial cells and plays an important role in the mechanism of cancer metastasis, regulating the adhesion of circulating cancer cells to the blood vessels. Our aim was to investigate the association of these molecules most common gene polymorphisms with gastric cancer (GC) susceptibility. Methods : We performed a case-control study of 88 gastric cancer cases and 480 controls to analyze the association between CASP8 -652 6N ins/del, CASP9 -1263 A>G, SDF1-3'A, survivin promoter -31G/C and E-selectin S128R gene polymorphisms and GC susceptibility. The genotyping analysis was done by Polymerase chain reaction -restriction fragment length polymorphism method. Results : CASP8 -652 6N ins/del polymorphism and CASP9 -1263 GG genotype were observed to be significantly associated with a lower risk of gastric cancer. Both CASP8 del/del and CASP9 -1263 GG genotypes were associated with increased overall survival in gastric cancer patients. The SDF1-3'A genotype frequencies for GG, GA and AA were 44.32, 48.86 and 6.92% in patients and 42.71, 47.71 and 9.58% in healthy subjects, respectively. GA+AA genotype frequency and A allele distribution were not identified as significantly different between gastric cancer cases and controls. The survivin frequencies for GG, GC and CC were 20.45, 50 and 29.54% in patients and 33.96, 45 and 21.04% in control group, respectively. The C carriers (GC+CC genotype) and the C allele were over-represented among the gastric cancer cases (P=0.013 and P=0.0083, respectively). The E-selectin S128R C allele, CA and CC genotypes were over-represented among the GC cases. However, carrying the C allele was associated with poor ...
Titel: |
Παράγοντες του στρώματος του όγκου και αποπτωτικά μόρια στον γαστρικό καρκίνο ; Tumor stroma factors and apoptotic molecules in gastric cancer
|
---|---|
Autor/in / Beteiligte Person: | Liarmakopoulos, Emmanouil ; Λιαρμακόπουλος, Εμμανουήλ |
Link: | |
Veröffentlichung: | National and Kapodistrian University of Athens ; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ), 2019 |
Medientyp: | Hochschulschrift |
DOI: | 10.12681/eadd/46793 |
Schlagwort: |
|
Sonstiges: |
|