Bacillus subtilis NDmed, a model strain for biofilm genetic studies
In: ISSN: 2590-2075, 2023
Online
academicJournal
Zugriff:
International audience ; The Bacillus subtilis strain NDmed was isolated from an endoscope washer-disinfector in a medical environment. NDmed can form complex macrocolonies with highly wrinkled architectural structures on solid medium. In static liquid culture, it produces thick pellicles at the interface with air as well as remarkable highly protruding ‘‘beanstalk-like’’ submerged biofilm structures at the solid surface. Since these mucoid submerged structures are hyper-resistant to biocides, NDmed has the ability to protect pathogens embedded in mixed-species biofilms by sheltering them from the action of these agents. Additionally, this non-domesticated and highly biofilm forming strain has the propensity of being genetically manipulated. Due to all these properties, the NDmed strain becomes a valuable model for the study of B. subtilis biofilms. This review focuses on several studies performed with NDmed that have highlighted the sophisticated genetic dynamics at play during B. subtilis biofilm formation. Further studies in project using modern molecular tools of advanced technologies with this strain, will allow to deepen our knowledge on the emerging properties of multicellular bacterial life.
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Bacillus subtilis NDmed, a model strain for biofilm genetic studies
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Autor/in / Beteiligte Person: | Dergham, Yasmine ; Le Coq, Dominique ; Bridier, Arnaud ; Sanchez-Vizuete, Pilar ; Jbara, Hadi ; Deschamps, Julien ; Hamze, Kassem ; Yoshida, Ken-Ichi ; Noirot-Gros, Marie-Françoise ; Briandet, Romain ; MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) ; الجامعة اللبنانية بيروت = Lebanese University Beirut = Université libanaise Beyrouth (LU / ULB) ; Centre National de la Recherche Scientifique (CNRS) ; Laboratoire de Fougères -, ANSES ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) ; University, Kobe |
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Zeitschrift: | ISSN: 2590-2075, 2023 |
Veröffentlichung: | HAL CCSD ; Elsevier B.V, 2023 |
Medientyp: | academicJournal |
ISBN: | 978-0-01-071172-1 (print) ; 0-01-071172-4 (print) |
DOI: | 10.1016/j.bioflm.2023.100152 |
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