Hydrotrope dynamics: unraveling solubility pattern and correlation of benzimidazole using response surface methodology expert system ...
Taylor & Francis, 2024
academicJournal
Zugriff:
Solubilizing drugs in liquid and semisolid environments typically involves the use of cosolvents or surfactants. In contrast, the utilization of hydrotropic agents, which are small hydrophilic organic compounds like sodium salicylate or sodium benzoate, has been less explored in the field of pharmaceutical formulations. However, particularly in the context of topical dosage forms, hydrotropic solubilization can present valuable alternatives for enhancing solubility. One challenge in employing hydrotropic solubilization has been the unpredictability of its effectiveness with different drug molecules. In the current study, three different hydrotropes namely sodium salicylate, sodium benzoate, and pyrogallol were chosen to test the solubility enhancement of benzimidazole drug. Optimization of solubility was proceeded with Central Composite Design obtained from RSM expert system. It was noticed from the results that sodium salicylate had performed the best compared to the other two chosen hydrotropes. This was ...
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Hydrotrope dynamics: unraveling solubility pattern and correlation of benzimidazole using response surface methodology expert system ...
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Autor/in / Beteiligte Person: | Natarajan, Arunodhaya ; Annal, Umaiyambika Neduvel ; Elakiyaasokan, Vasanth Kumar ; Nagarajan, Nagendra Gandhi |
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Veröffentlichung: | Taylor & Francis, 2024 |
Medientyp: | academicJournal |
DOI: | 10.6084/m9.figshare.25296263.v1 |
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