A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken ( Gallus domesticus ) model in comparison to ketoconazole
In: BMC Veterinary Research, Vol 8, Iss 1, p 210 (2012, Jg. 8 (2012), Heft 1, p 210
Online
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Zugriff:
Background The poultry industry due to intensive methods of farming is burdened with losses from numerous infectious agents, of which one is the fungus Aspergillus fumigatus . In a preliminary study, the extracts of Loxostylis alata A. Spreng, ex Rchb. showed good activity in vitro against A. fumigatus with a minimum inhibitory concentration of 0.07 mg/ml. For this study crude, a crude acetone extract of L. alata leaves was evaluated for its acute toxicity in a healthy chicken model and for efficacy in an infectious model of aspergillosis ( A. fumigatus ). Results At a dose of 300 mg/kg, the extract induced some toxicity characterised by decreased feed intake and weight loss. Consequently, 100 and 200 mg/kg were used to ascertain efficacy in the infectious model. The plant extract significantly reduced clinical disease in comparison to the control in a dose dependant manner. The extract was as effective as the positive control ketoconazole dosed at 60 mg/kg. Conclusions The results indicate that a crude extract of L. alata leaves has potential as an antifungal agent to protect poultry against avian aspergillosis.
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A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken ( Gallus domesticus ) model in comparison to ketoconazole
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Autor/in / Beteiligte Person: | Suleiman Mohammed, M ; Neil, Duncan ; Eloff Jacobus, N ; Vinny, Naidoo |
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Zeitschrift: | BMC Veterinary Research, Vol 8, Iss 1, p 210 (2012, Jg. 8 (2012), Heft 1, p 210 |
Veröffentlichung: | BMC, 2012 |
Medientyp: | academicJournal |
ISSN: | 1746-6148 (print) |
DOI: | 10.1186/1746-6148-8-210 |
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