Immediate Response to Brentuximab Vedotin in a Patient with Localized MF-LCT
In: Case Reports in Dermatology, Jg. 15 (2023), Heft 1, S. 110-116
Online
academicJournal
Zugriff:
The large cell transformation of mycosis fungoides (MF-LCT) is a phenomenon observed in the advanced stages of mycosis fungoides (MF), which is the most common primary cutaneous lymphoma. The diagnostic criteria of MF-LCT are a minimum of 25% of large cells or a formation of microscopic nodules of them in the histological examination of skin samples. The clinical outcomes for MF-LCT are poor, as less than 20% of patients survive 5 years after diagnosis, but the expression of the CD30 antigen is generally considered to be associated with a better prognosis. We present a case of a patient with the diagnosis of MF with LCT, with an ulcerated tumor lesion approximately 30 × 20 cm in size on the right lateral abdominal wall. Brentuximab vedotin (BV) treatment was started due to the presence of the CD30 antigen, with a quick and impressive regression of the cutaneous lesion and tumor mass and good treatment tolerance. After follow-up of 20 months, patient remains in complete remission. A schedule of treatment for MF-LCT is directed mainly by the clinical stage of the disease and the comorbidities; the more severe clinical course of the disease requires systemic treatment. If at least 5% of the cells found in the skin lesions biopsy sample express the CD30 antigen, a beneficial effect of BV treatment could be expected. It may seem that the use of BV is one of the optimal therapeutic options in patients with advanced MF-LCT showing expression of CD30.
Titel: |
Immediate Response to Brentuximab Vedotin in a Patient with Localized MF-LCT
|
---|---|
Autor/in / Beteiligte Person: | Giza, Agnieszka ; Miklusiak, Karol ; Hałubiec, Przemysław ; Jaworek, Andrzej ; Zimowska-Curyło, Dagmara ; Dyduch, Grzegorz ; Sacha, Tomasz |
Link: | |
Zeitschrift: | Case Reports in Dermatology, Jg. 15 (2023), Heft 1, S. 110-116 |
Veröffentlichung: | Karger Publishers, 2023 |
Medientyp: | academicJournal |
ISSN: | 1662-6567 (print) |
DOI: | 10.1159/000529576 |
Schlagwort: |
|
Sonstiges: |
|