Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach
In: ISSN: 1368-8375 ; Oral Oncology ; https://univ-rennes.hal.science/hal-02177701 ; Oral Oncology, 2019, 94, pp.47-57. ⟨10.1016/j.oraloncology.2019.05.006⟩, 2019
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Zugriff:
International audience ; OBJECTIVES: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. MATERIALS AND METHODS: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. RESULTS: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. CONCLUSION: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.
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Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach
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| Autor/in / Beteiligte Person: | Di Credico, Gioia ; Edefonti, Valeria ; Polesel, Jerry ; Pauli, Francesco ; Torelli, Nicola ; Serraino, Diego ; Negri, Eva ; Luce, Daniele ; Stucker, Isabelle ; Matsuo, Keitaro ; Brennan, Paul ; Vilensky, Marta ; Fernandez, Leticia ; Curado, Maria Paula ; Menezes, Ana ; Daudt, Alexander ; Koifman, Rosalina ; Wunsch-Filho, Victor ; Holcátová, Ivana ; Ahrens, Wolfgang ; Lagiou, Pagona ; Simonato, Lorenzo ; Richiardi, Lorenzo ; Healy, Claire ; Kjaerheim, Kristina ; Conway, David ; Macfarlane, Tatiana ; Thomson, Peter ; Agudo, Antonio ; Znaor, Ariana ; Boaventura Rios, Leonardo ; Toporcov, Tatiana ; Franceschi, Silvia ; Herrero, Rolando ; Muscat, Joshua ; Olshan, Andrew, F. ; Zevallos, Jose ; La Vecchia, Carlo ; Winn, Deborah ; Sturgis, Erich ; Li, Guojun ; Fabianova, Eleonora ; Lissowska, Jolanda ; Mates, Dana ; Rudnai, Peter ; Shangina, Oxana ; Swiatkowska, Beata ; Moysich, Kirsten ; Zhang, Zuo-Feng ; Morgenstern, Hal ; Levi, Fabio ; Smith, Elaine ; Lazarus, Philip ; Bosetti, Cristina ; Garavello, Werner ; Kelsey, Karl ; Mcclean, Michael ; Ramroth, Heribert ; Chen, Chu ; Schwartz, Stephen ; Vaughan, Thomas ; Zheng, Tongzhang ; Menvielle, Gwenn ; Boccia, Stefania ; Cadoni, Gabriella ; Hayes, Richard ; Purdue, Mark, P. ; Gillison, Maura ; Schantz, Stimson ; Yu, Guo-Pei ; Brenner, Hermann ; d'Souza, Gypsyamber ; Gross, Neil ; Chuang, Chu ; Boffetta, Paolo ; Hashibe, Mia ; Yu, Yuan-Chin Amy ; Dal Maso, Luigino ; Università degli Studi di Milano = University of Milan (UNIMI) ; Institut de recherche en santé, environnement et travail (Irset) ; Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) ; Centre de recherche en épidémiologie et santé des populations (CESP) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC) ; Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO) ; University of Glasgow ; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) ; TW001500, National Institutes of Health ; P30ES010126, National Institute of Environmental Health Sciences ; Italian Ministry of Education ; Università degli Studi di Milano ; Jonsson Comprehensive Cancer Center ; International Union Against Cancer ; Fondo para la Investigacion Cientifica y Tecnologica Argentina ; Institut Hospital del Mar d’Investigacions Mediquès (IMIM) ; Fundação de Amparo à Pesquisa no Estado de São Paulo ; Government, Spanish ; Community, European ; Ministry of Science, Research and Arts Baden-Wurttemberg ; German Ministry of Education and Research ; Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan ; Labor and Welfare of Japan ; Italian Foundation for Cancer Research |
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| Zeitschrift: | ISSN: 1368-8375 ; Oral Oncology ; https://univ-rennes.hal.science/hal-02177701 ; Oral Oncology, 2019, 94, pp.47-57. ⟨10.1016/j.oraloncology.2019.05.006⟩, 2019 |
| Veröffentlichung: | HAL CCSD ; Elsevier, 2019 |
| Medientyp: | academicJournal |
| DOI: | 10.1016/j.oraloncology.2019.05.006 |
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