Spanish Lung Cancer Group SCAT trial: surgical audit to lymph node assessment based on IASLC recommendations
Ame publ co, 2021
Online
academicJournal
Zugriff:
Background: The Spanish Customized Adjuvant Therapy (SCAT) trial assessed the role of individualized adjuvant therapy in clinical N0 incidental pN1 and/or N2 non-small cell lung cancer (NSCLC) completely resected. We assessed surgical topics with an in-depth analysis of quality of lymphadenectomy based on International Association for the Study of Lung Cancer (IASLC) recommendations.Methods: Patients with information about lymphadenectomy available were included (N=451). Prospectively collected data about tumor, type of resection, and postoperative morbidity and quality of lymph node dissection (LND) were retrospectively evaluated. Role of lymph node assessment on survival was analyzed using Kaplan-Meier curves, using regression models to identify prognostic factors.Results: In 33.7%, 17.7% and 49.9% of cases, regions 7, 10 and 11 respectively were not assessed. In 21.1% of patients, less than three lymph node regions were biopsied, while in 19.6% of patients less than six lymph nodes were assessed. In 53,4% of patients only one N1 region was evaluated. From patients with positive N2, 8.9% had no N1 regions biopsied. Twenty-nine percent of patients with at least one N2 lymph node resected shown the highest region involved. Thirty-day postoperative mortality was unknown. Five-year overall survival (OS) was 61.7% (95% CI: 55.4-67.4%), 51.5% (95% CI: 39.2-62.4%) and 42.3% (95% CI: 32.1-52.2%) for patients with N1, N2 and N1+N2 disease, respectively (P
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Spanish Lung Cancer Group SCAT trial: surgical audit to lymph node assessment based on IASLC recommendations
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Autor/in / Beteiligte Person: | Jarabo Sarceda, Jose Ramon ; Bolufer Nadal, Sergio ; Mongil Poce, Roberto ; Lopez de Castro, Pedro ; Moreno Balsalobre, Ramon ; Penalver Cuesta, Juan Carlos ; Embun Flor, Raul ; Pac Ferrer, Joaquin ; Algar Algar, Francisco Javier ; Gamez Garcia, Antonio Pablo ; Jimenez, Marcelo F. ; Gabriel Sales-Badia, Jesus ; Pereira, Eva ; Massuti, Bartomeu ; Provencio, Mariano ; Hernando Trancho, Florentino ; Jarabo Sarceda, Jose Ramon Hosp Clin San Carlos, Dept Thorac Surg, Madrid, Spain ; Hernando Trancho, Florentino Hosp Clin San Carlos, Dept Thorac Surg, Madrid, Spain ; Bolufer Nadal, Sergio Hosp Univ Alicante, Dept Thorac Surg, Alicante, Spain ; Mongil Poce, Roberto Hosp Univ Malaga, Dept Thorac Surg, Malaga, Spain ; Lopez de Castro, Pedro Hosp Badalona Germans Trias & Pujol, Dept Thorac Surg, Barcelona, Spain ; Moreno Balsalobre, Ramon Hosp Univ Princesa, Dept Thorac Surg, Madrid, Spain ; Penalver Cuesta, Juan Carlos Inst Valenciano Oncol, Dept Thorac Surg, Valencia, Spain ; Embun Flor, Raul Hosp Univ Miguel Servet, Dept Thorac Surg, IIS Aragon, Zaragoza, Spain ; Pac Ferrer, Joaquin Hosp Univ Cruces, Dept Thorac Surg, Bilbao, Spain ; Algar Algar, Francisco Javier Hosp Univ Reina Sofia Cordoba, Dept Thorac Surg, Cordoba, Spain ; Gamez Garcia, Antonio Pablo Hosp Univ 12 Octubre, Dept Thorac Surg, Madrid, Spain ; Jimenez, Marcelo F. Hosp Univ Salamanca, Dept Thorac Surg, Salamanca, Spain ; Gabriel Sales-Badia, Jesus Hosp Univ Fe, Dept Thorac Surg, Valencia, Spain ; Pereira, Eva Spanish Lung Canc Grp, Barcelona, Spain ; Massuti, Bartomeu Hosp Univ Alicante, Dept Med Oncol, Alicante, Spain ; Provencio, Mariano Hosp Univ Puerta Hierro Majadahonda, Dept Oncol, Madrid, Spain ; Sanofi-Aventis |
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Veröffentlichung: | Ame publ co, 2021 |
Medientyp: | academicJournal |
ISSN: | 2218-6751 (print) ; 2226-4477 (print) |
DOI: | 10.21037/tlcr-20-1055 |
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