Noncanonical sequences in LTF-responsive promoters.
2021
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Zugriff:
( A ) Proportional distribution of different motif types in LTF-responsive promoters by tertile rank in TSR strength. Based on effects of UL79 H F LTF depletion (6-h dTag treatment) on viral TSR strength at 72 hpi. Null, unclassified sequence. ( B ) MEME logo determination for UL87 LTF-responsive TSRs having a TATAT positioned -50 to -20 relative to MAXTSS by tertile rank in TSR strength. ( C-E ) Effect of UL79 H F LTF depletion on viral TSR strength at 72 hpi versus baseline TSR strength (C and E) or PSI (D) for viral TSRs ≥435 nascent RNA reads (open circles). Viral TSRs with TATT (red), TATAT (pink), TATAA (blue), TGTT (green), or YRYT (violet) sequences positioned -40 to -28 relative to MAXTSS are marked with dots colored accordingly. Horizontal dashed line divides top and mid TSR strength tertiles. ( F ) Effect of dTag treatment for 2 versus 6 h on viral TSR strength (dTag/CTRL) at 96 hpi for HCMV UL87 H F. Viral TSR strength was determined by spike-in normalized PRO-Seq-Flavo method. Arrows point to viral asUL49 and RL10 TSRs having upstream TGTT and TACT sequences, respectively.
Titel: |
Noncanonical sequences in LTF-responsive promoters.
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Autor/in / Beteiligte Person: | Ming Li (91180) ; Qiaolin Hu (8677473) ; Geoffrey Collins (7005227) ; Mrutyunjaya Parida (11218645) ; Christopher B. Ball (564991) ; David H. Price (8677476) ; Jeffery L. Meier (8677479) |
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Veröffentlichung: | 2021 |
Medientyp: | Bild |
DOI: | 10.1371/journal.ppat.1009796.g007 |
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