Aspects to T-cell phenotype during infection with HIV, CMV and Hepatitis C virus
University of Oxford, 2008
Online
Hochschulschrift
Zugriff:
This work concerns itself with understanding the organisation of cellular immune responses to three major human pathogens - HIV, CMV and Hepatitis C (HCV). Each was studied to form three projects, each undertaken with a different approach - arrived at independently - and largely owing their origins to opportunity and circumstance as much as design. Each project led to exploration of a particular aspect of T-cell phenotype (that is the expression of particular molecular markers on T-cells) and its’ broader biological significance. I found that T-cell phenotype was strongly linked to the magnitude of T-cell responses (CMV) and the ability of T-cells to control infection (HIV). Finally I explored the significance of expression of a molecule known as CD161 on the surface of HCV specific CD8+ T-cells, indicating a phenotype of T-cell that may not follow the ‘normal rules’ applicable to T-cells in general.
Titel: |
Aspects to T-cell phenotype during infection with HIV, CMV and Hepatitis C virus
|
---|---|
Autor/in / Beteiligte Person: | Northfield, John ; Klenerman, Paul |
Link: | |
Veröffentlichung: | University of Oxford, 2008 |
Medientyp: | Hochschulschrift |
Schlagwort: |
|
Sonstiges: |
|