Synthesis of the N-Allylthioamide Derivatives of Cyclic Oxo- and Dioxo- Acids and Their Cyclization to the Derivatives of 4,5-Dihydrothiazole
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serialPeriodical
Zugriff:
The title N-allylthioamides (1a-f) were synthesized in the reaction of allyl isothiocyanate with enamines (1a-c) and 1,3-diketones (1d-f), respectively, carried out in an acetonitrile solution in the presence of DBU. When treated with the bromine-dioxane complex or with iodine, they underwent cyclization to the corresponding derivatives of 4,5-dihydrothiazole (2a-g). NMR spetroscopy made it possible to elucidate the tautomeric structures of the thioamides and thiazolines.
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Synthesis of the N-Allylthioamide Derivatives of Cyclic Oxo- and Dioxo- Acids and Their Cyclization to the Derivatives of 4,5-Dihydrothiazole
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Autor/in / Beteiligte Person: | Wesołowska, A. ; Jagodziński, T. S. ; Sośnicki, J. G. ; Hansen, P. E. |
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Medientyp: | serialPeriodical |
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