Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis after stem cell transplantation : effective monitoring of CMV infection by quantitative analysis of CMV mRNA

OHTA, H ; MATSUDA, Y ; et al.

In: Bone marrow transplantation (Basingstoke), Jg. 27 (2001), Heft 11, S. 1141-1145

Online academicJournal - print, 19 ref

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We report three pediatric patients with ganciclovir-resistant cytomegalovirus (CMV) retinitis who were successfully treated with foscarnet. The patients were recipients of hematopoietic stem cell transplantation (SCT) from HLA-mismatched donors. Because these patients had developed or experienced progressive CMV retinitis during ganciclovir therapy, they received foscarnet therapy at 60 mg/kg every 8 h. Their retinitis resolved promptly after initiating foscarnet therapy, suggesting foscarnet's effectiveness in treating ganciclovir-resistant CMV infection. The amount of CMV mRNA was quantitatively measured using an NASBA technique, which amplified the β2.7 transcripts specific for CMV replication. This technique was useful for monitoring disease activity in a more rapid and sensitive manner than the PCR assay for CMV DNA.

Titel:	Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis after stem cell transplantation : effective monitoring of CMV infection by quantitative analysis of CMV mRNA
Autor/in / Beteiligte Person:	OHTA, H ; MATSUDA, Y ; TANO, Y ; AONO, T ; YAMANISHI, K ; OKADA, S ; HARA, J ; TOKIMASA, S ; SAWADA, A ; KIM, J. Y ; SASHIHARA, J ; AMO, K ; MIYAGAWA, H ; TANAKA-TAYA, K ; YAMAMOTO, S
Link:	Volltext (PDF) View record from PASCAL Archive
Zeitschrift:	Bone marrow transplantation (Basingstoke), Jg. 27 (2001), Heft 11, S. 1141-1145
Veröffentlichung:	Basingstoke: Nature Publishing Group, 2001
Medientyp:	academicJournal
Umfang:	print, 19 ref
ISSN:	0268-3369 (print)
Schlagwort:	Medical oncology Cancérologie Graft, transplantation Greffe, transplantation Hematology Hématologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Antibiotiques. Antiinfectieux. Antiparasitaires Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviraux Antiviral agents Betaherpesvirinae Enzyme Enzima Herpesviridae Homme Human Hombre Hémopathie maligne Malignant hemopathy Hemopatía maligna Infection Infección Lymphoprolifératif syndrome Lymphoproliferative syndrome Linfoproliferativo síndrome Oeil pathologie Eye disease Ojo patología Rétinopathie Retinopathy Retinopatía Transferases Virus Adolescent Adolescente Aigu Acute Agudo Analyse quantitative Quantitative analysis Análisis cuantitativo Antiviral Cellule hématopoïétique Hematopoietic cell Célula hematopoyética Cellule souche Stem cell Célula primitiva Chimiothérapie Chemotherapy Quimioterapia Complication Complicación Cytomegalovirus humain Human cytomegalovirus Enfant Child Niño Etude cas Case study Estudio caso Femelle Female Hembra Foscarnet sodique Foscarnet sodium Foscarnet sódico Ganciclovir Homogreffe Homograft Homoinjerto Inhibiteur enzyme Enzyme inhibitor Inhibidor enzima Leucémie lymphoblastique Acute lymphocytic leukemia Leucemia linfoblástica Leucémie myéloblastique Acute myelocytic leukemia Leucemia mieloblástica Nucleotidyltransferases Nucléoside acyclique Acyclic nucleoside Nucleósido acíclico Purine nucléoside Purine nucleoside Purina nucleósido RNA messager Messenger RNA RNA mensajero Résistance traitement Negative therapeutic reaction Resistencia al tratamiento terapeútico Rétinite Retinitis Sang Blood Sangre Surveillance Vigilancia Traitement Treatment Tratamiento Virose Viral disease Virosis
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Developmental Medicine (Pediatrics), Osaka University Graduate School of Medicine, Suita, Osaka, Japan ; Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan ; Toyobo Research Center, Ohtsu, Japan ; Department of Microbiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan Rights: Copyright 2001 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Pharmacological treatments

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