Protein kinase C gamma-like immunoreactivity in the substantia gelatinosa of the medullary dorsal horn of the rat
In: Neuroscience letters, Jg. 311 (2001), Heft 3, S. 185-188
academicJournal
- print, 20 ref
Zugriff:
We examined protein kinase C gamma-immunoreactivity (PKCγ-IR) in the substantia gelatinosa (SG) of the rat medullary dorsal horn (MDH). The density of PKCγ-IR in the MDH was most intense in the SG. The number of neurons with PKCγ-IR were also much larger in the SG than in the other layers of the MDH. Double-immunohistochemical studies indicated light and electron microscopically that substance P-containing fibers and I-B4 (isolectin from Bandeiraea simplicifolia)-labeled fibers made synapses on SG neurons with PKCγ-IR, indicating that SG neurons with PKCγ might receive nociceptive primary afferent fibers. The results support the notion that PKCγ in the MDH may contribute to the regulation of the nociception.
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Protein kinase C gamma-like immunoreactivity in the substantia gelatinosa of the medullary dorsal horn of the rat
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Autor/in / Beteiligte Person: | LI, Jin-Lian ; LI, Yun-Qing ; NOMURA, Sakashi ; KANEKO, Takeshi ; MIZUNO, Noboru |
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Zeitschrift: | Neuroscience letters, Jg. 311 (2001), Heft 3, S. 185-188 |
Veröffentlichung: | Shannon: Elsevier, 2001 |
Medientyp: | academicJournal |
Umfang: | print, 20 ref |
ISSN: | 0304-3940 (print) |
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