Indirect determination of paracetamol in pharmaceutical formulations by inhibition of the system luminol - H2O2- Fe(CN)3-6 chemiluminescence
In: Journal of pharmaceutical and biomedical analysis, Jg. 21 (1999), Heft 2, S. 311-317
academicJournal
- print, 30 ref
Zugriff:
After a large drug scanning, the system Luminol-H2O2 Fe(CN)3-6 is proposed for first time for the indirect determination of paracetamol. The method is based on the oxidation of paracetamol by hexacyanoferrate (III) and the subsequent inhibitory effect on the reaction between luminol and hydrogen peroxide. The procedure resulted in a linear calibration graph over the range 2.5-12.5 μg ml-1 of paracetamol with a sample throughput of 87 samples h-1. The influence of foreign compounds was studied and, the method was applied to determination of the drug in three different pharmaceutical formulations.
Titel: |
Indirect determination of paracetamol in pharmaceutical formulations by inhibition of the system luminol - H2O2- Fe(CN)3-6 chemiluminescence
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Autor/in / Beteiligte Person: | ALAPONT, A. G ; LAHUERTA ZAMORA, L ; MARTINEZ CALATAYUD, J |
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Zeitschrift: | Journal of pharmaceutical and biomedical analysis, Jg. 21 (1999), Heft 2, S. 311-317 |
Veröffentlichung: | Amsterdam: Elsevier Science, 1999 |
Medientyp: | academicJournal |
Umfang: | print, 30 ref |
ISSN: | 0731-7085 (print) |
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