Role of the cytomegalovirus (CMV)-antigenemia assay as a predictive and follow-up detection tool for CMV disease in aids patients

HOSHINO, Y ; NAGATA, Y ; et al.

In: Microbiology and immunology, Jg. 43 (1999), Heft 10, S. 959-965

Online academicJournal - print, 21 ref

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Forty-two patients were evaluated to determine the value of the CMV antigenemia (CMV-Ag) test as a follow-up marker as well as a prediction marker of CMV disease. Twenty patients were positive for at least one positive CMV-Ag assay and 9 of them developed CMV retinitis. With the threshold value (10 positive cells), sensitivity was 56% and specificity was 94%. The CMV-Ag assay, with the threshold value, produced high specificity, positive predictive value and negative predictive value but relatively poor sensitivity. Eight patients experienced CMV disease relapse a total of 16 times. At relapse, 8 of the 16 times showed negative for CMV-Ag assay; 7 underwent systemic maintenance while 1 underwent local maintenance. It is inferred that the CMV-Ag test is a poor follow-up marker to detect the relapse of CMV disease, particularly in patients undergoing systemic maintenance.

Titel:	Role of the cytomegalovirus (CMV)-antigenemia assay as a predictive and follow-up detection tool for CMV disease in aids patients
Autor/in / Beteiligte Person:	HOSHINO, Y ; NAGATA, Y ; TAGUCHI, H ; MASUNAGA, A ; FUJINO, Y ; MOCHIZUKI, M ; NAKAMURA, T ; IWAMOTO, A
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Microbiology and immunology, Jg. 43 (1999), Heft 10, S. 959-965
Veröffentlichung:	Tokyo: Center for Academic Publications Japan, 1999
Medientyp:	academicJournal
Umfang:	print, 21 ref
ISSN:	0385-5600 (print)
Schlagwort:	Biochemistry, molecular biology, biophysics Biochimie, biologie moléculaire, biophysique Immunology, immunopathology, allergology Immunologie, immunopathologie, allergologie Microbiology, infectious diseases Microbiologie, maladies infectieuses Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pathologie infectieuse Infectious diseases Viroses Viral diseases Viroses humaines Human viral diseases Divers Miscellaneous Betaherpesvirinae Herpesviridae Immunodéficit Immune deficiency Inmunodeficiencia Immunopathologie Immunopathology Inmunopatología Infection Infección Oeil pathologie Eye disease Ojo patología Rétinopathie Retinopathy Retinopatía Virose Viral disease Virosis Virus Antigène Antigen Antígeno Cellule infectée Infected cell Célula infectada Cytomegalovirus humain Human cytomegalovirus Diagnostic Diagnosis Diagnóstico Homme Human Hombre Infection opportuniste Opportunistic infection Infección oportunista Leucocyte Leukocyte Leucocito Pronostic Prognosis Pronóstico Récidive Relapse Recaida Rétinite Retinitis SIDA AIDS Antigènémie Antigenemia
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Infectious Diseases, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan ; Department of Ophthalmology, International Medical Center of Japan, Shinjuku-ku, Tokyo 162-8655, Japan ; Laboratory Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan ; Department of Ophthalmology, Tokyo Koseinenkin Hospital, Shinjuku-ku, Tokyo 162-8543, Japan ; Department of Ophthalmology, School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan ; Department of Infectious Diseases and Applied Immunology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan Rights: Copyright 2000 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Infectious pathology

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