Inhibition of gastric acid secretion in rat stomach by PACAP is mediated by secretin, somatostatin, and PGE2

LI, P ; CHANG, T.-M ; et al.

In: American journal of physiology. Gastrointestinal and liver physiology, Jg. 41 (2000), Heft 1, S. G121- (7S.)

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Pituitary adenylate cyclase-activating polypeptide (PACAP), existing in two variants, PACAP-27 and PACAP-38, is found in the enteric nervous system and regulates function of the digestive system. However, the regulatory mechanism of PACAP on gastric acid secretion has not been well elucidated. We investigated the inhibitory action of PACAP-27 on acid secretion and its mechanism in isolated vascularly perfused rat | stomach. PACAP-27 in four graded doses (5, 10, 20, and 50 μg/h) was vascularly infused to determine its effect on basal and pentagastrin (50 ng/h)-stimulated acid secretion. To study the inhibitory mechanism of PACAP-27 on acid secretion, a rabbit antisecretin serum, antisomatostatin serum, or indomethacin was administered. Concentrations of secretin, somatostatin, PGE2, and histamine in portal venous effluent were measured by RIA. PACAP-27 dose-dependently inhibited both basal and pentagastrin-stimulated acid secretion. PACAP-27 at 10 μg/h significantly increased concentrations of secretin, somatostatin, and PGE2 in basal or pentagastrin-stimulated state. The inhibitory effect of PACAP-27 on pentagastrin-stimulated acid secretion was reversed 33% by an antisecretin serum, 80.0% by an antisomatostatin serum, and 46.1% by indomethacin. The antisecretin serum partially reduced PACAP-27-induced local release of somatostatin and PGE2 PACAP-27 at 10 μg/h elevated histamine level in portal venous effluent, which was further increased by antisomatostatin serum. However, antisomatostatin serum did not significantly increase acid secretion. It is concluded that PACAP-27 inhibits both basal and pentagastrin-stimulated gastric acid secretion. The effect of PACAP-27 is mediated by local release of secretin, somatostatin, and PGE2 in isolated perfused rat stomach. The increase in somatostatin and PGE2 levels in portal venous effluent is, in part, attributable to local action of the endogenous secretin.

Titel:	Inhibition of gastric acid secretion in rat stomach by PACAP is mediated by secretin, somatostatin, and PGE2
Autor/in / Beteiligte Person:	LI, P ; CHANG, T.-M ; COY, D ; CHEY, W. Y
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	American journal of physiology. Gastrointestinal and liver physiology, Jg. 41 (2000), Heft 1, S. G121- (7S.)
Veröffentlichung:	Bethesda, MD: American Physiological Society, 2000
Medientyp:	academicJournal
Umfang:	print, 37 ref
ISSN:	0193-1857 (print)
Schlagwort:	Gastroenterology Gastroentérologie Physiology, morphology Physiologie, morphologie Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Vertebres: systeme digestif Vertebrates: digestive system Estomac Stomach Appareil digestif Digestive system Aparato digestivo Arachidonique acide dérivé Arachidonic acid derivatives Araquidónico ácido derivado Eicosanoïde Eicosanoid Eicosanoide Hormone gastrointestinale Gastrointestinal hormone Hormona gastrointestinal Mammalia Neuropeptide Neuropéptido Rodentia Vertebrata Acide Acids Acido Animal Estómago Inhibition Inhibición Peptide PACAP Pituitary adenylate cyclase activating peptide Péptido PACAP Prostaglandine E2 Prostaglandin E2 Prostaglandina E2 Rat Rata Somatostatine Somatostatin Somatostatina Sécrétine Secretin Secretina Sécrétion exocrine Exocrine secretion Secreción exocrina
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Konar Center for Digestive and Liver Diseases, University of Rochester Medical Center, Rochester, New York 14642, United States ; Tulane University Medical Center, New Orleans, Louisiana 70112, United States Rights: Copyright 2000 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Vertebrates : digestive and urinary system

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