Neurons in the monoaminergic nuclei of the rat and human central nervous system express FAI/dlk
In: Neuroreport (Oxford), Jg. 12 (2001), Heft 18, S. 3959-3963
Online
academicJournal
- print, 25 ref
Zugriff:
The gene DLK1 encodes a member of the epidermal growth factor (EGF) superfamily, delta-like (dlk). When exposed in vivo to the action of an unknown protease, this type I membrane protein generates a soluble peptide referred to as Fetal antigen I (FAI). By acting in juxtacrine as well as paracrine/autocrine manners, both forms have been shown to be active in the differentiation/proliferation process of various cell types. In adults, FAI/dlk has been demonstrated mainly within (neuro) endocrine tissues. In this study we investigated the presence of FAI/dlk in other parts of the developing and adult rat and human CNS. Using immunocytochemistry and in situ hybridization we found that in both species FAI/dlk was expressed in neurons of the Edinger-Westphal's nucleus as well as in substantia nigra, ventral tegmental area (VTA), locus coeruleus and in certain parts of the raphe nuclei.
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Neurons in the monoaminergic nuclei of the rat and human central nervous system express FAI/dlk
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Autor/in / Beteiligte Person: | JENSEN, Charlotte Harken ; MEYER, Morten ; SCHRODER, Henrik Daa ; KLIEM, Anette ; ZIMMER, Jens ; TEISNER, Børge |
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Zeitschrift: | Neuroreport (Oxford), Jg. 12 (2001), Heft 18, S. 3959-3963 |
Veröffentlichung: | Hagerstown, MD: Lippincott Williams and Wilkins, 2001 |
Medientyp: | academicJournal |
Umfang: | print, 25 ref |
ISSN: | 0959-4965 (print) |
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