Clinical and metabolic effects of two lipid emulsions on the parenteral nutrition of septic patients
In: Nutrition (Burbank, Los Angeles County, Calif.), Jg. 18 (2002), Heft 2, S. 134-138
academicJournal
- print, 29 ref
Zugriff:
OBJECTIVE: We compared the metabolic and clinical effects of two lipid emulsions, long-chain triacylglycerols (LCT) and a mixture of medium- and long-chain triacylglycerols (MCT/LCT), in septic patients. METHODS: Both groups received total parenteral nutrition (TPN) with a solution enriched with branched-chain amino acids (BCAA). Seventy-two septic patients received TPN with MCT/LCT (group 1) or LCT (group 2). Before starting TPN (basal) and 10 d after (final), various parameters were evaluated. RESULTS: Twenty-six subjects in each group completed the study. Both groups showed an increase in cholestasis enzymes, with no significant changes in lipid parameters. The rise of retinol-binding protein and the recovery of nitrogen balance were significantly greater in group 1. A multivariate analysis of nutritional markers and catabolic parameters showed a better evolution in group 1 (P = 0.002). The MCT/LCT group exhibited a significant increase of insulin levels. Overall mortality and length of stay in the intensive care unit were not affected by the lipid emulsion. CONCLUSIONS: In septic patients who received TPN with a solution enriched with BCAAs, the use of an emulsion containing MCT provided them with a greater recovery of their nutrition status than the traditional LCT formula, without influencing the outcome.
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Clinical and metabolic effects of two lipid emulsions on the parenteral nutrition of septic patients
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Autor/in / Beteiligte Person: | GARNACHO-MONTERO, J ; ORTIZ-LEYBA, C ; JIMENEZ-JIMENEZ, F. J ; GARCIA-GARMENDIA, J. L ; JIMENEZ JIMENEZ, L. M ; GARNACHO-MONTERO, M. C ; BARRERO-ALMODOVAR, A |
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Zeitschrift: | Nutrition (Burbank, Los Angeles County, Calif.), Jg. 18 (2002), Heft 2, S. 134-138 |
Veröffentlichung: | New York, NY: Elsevier, 2002 |
Medientyp: | academicJournal |
Umfang: | print, 29 ref |
ISSN: | 0899-9007 (print) |
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