The role of NPY in the mediation of orexin-induced hypothermia
In: Orexin, Jg. 104 (2002), Heft 1-3, S. 55-59
academicJournal
- print, 34 ref
Zugriff:
The mediation of orexin-A-induced hypothermia was investigated. Different doses of orexin-A (140-560 pmol) were administered intracerebroventricularly (i.c.v.) to adult male rats, and the colon temperature was used as an index of the thermoregulatory action. Orexin-A decreased both the basal colon temperature and the lipopolysaccharide-induced fever and exhibited a bell-shaped dose-response curve. I.c.v. pretreatment with neuropeptide Y (NPY) antiserum 24 h before orexin administration significantly decreased the hypothermic effect of orexin-A. These data strengthen the hypothesis that this appetite-regulating peptide might also play a role in thermoregulation, and its hypothermic effect seems to be mediated at least partially by NPY.
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The role of NPY in the mediation of orexin-induced hypothermia
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Autor/in / Beteiligte Person: | JASZBERENYI, Miklos ; BUJDOSO, Erika ; KISS, Edina ; PATAKI, Imre ; TELEGDY, Gyula |
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Zeitschrift: | Orexin, Jg. 104 (2002), Heft 1-3, S. 55-59 |
Veröffentlichung: | Amsterdam; Shannon: Elsevier, 2002 |
Medientyp: | academicJournal |
Umfang: | print, 34 ref |
ISSN: | 0167-0115 (print) |
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