Electrolytic lesions of the cortical and adjacent nuclei in the amygdala differentially influence thresholds for rewarding medial forebrain bundle stimulation
In: Behavioral neuroscience, Jg. 116 (2002), Heft 4, S. 660-671
Online
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- print, 1 p.1/4
Zugriff:
After electrolytic lesions to the cortical and adjacent amygdaloid subnuclei, thresholds for rewarding medial forebrain bundle (MFB) stimulation were tracked in 19 rats with bilateral implants and 8 with single implants. Results were categorized into 3 groups depending on the magnitude of the lesion effect on ipsilateral frequency thresholds: substantial (> 60%). small (> 26%), or none (< 26%), compared with baseline values. Five rats exhibited threshold increases up to 225%, among the largest reported to the authors' knowledge. Small shifts were observed in another 5 rats, and no change in the remaining 17 rats. Threshold changes in the contralateral electrode mirrored ipsilateral ones. Results suggest that specific amygdaloid subnuclei modulate MFB reward signals through a diffuse collateralized organization of fibers and lend support to the existence of interhemispheric links in MFB reward pathways.
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Electrolytic lesions of the cortical and adjacent nuclei in the amygdala differentially influence thresholds for rewarding medial forebrain bundle stimulation
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Autor/in / Beteiligte Person: | BIELAIEW, Catherine ; MIGUELEZ, Maïa ; SHIAO, Renfu |
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Zeitschrift: | Behavioral neuroscience, Jg. 116 (2002), Heft 4, S. 660-671 |
Veröffentlichung: | Washington, DC: American Psychological Association, 2002 |
Medientyp: | academicJournal |
Umfang: | print, 1 p.1/4 |
ISSN: | 0735-7044 (print) |
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