Abnormal FHITt expression profiles in cervical intraepithelial neoplastic (CIN) lesions
In: British journal of cancer, Jg. 86 (2002), Heft 3, S. 376-381
Online
academicJournal
- print, 29 ref
Zugriff:
Abnormal fragile histidine triad transcripts were found in 20-30% of ClN2/3 lesions and 11% of normal cervical biopsies by RT-PCR. Bi-allelic loss of the fragile histidine triad gene and the loss of fragile histidine triad protein expression detectable by immunochemical staining with a polyclonal fragile histidine triad specific antibody was rare. The genomic changes showed no association with the presence of human papillomavirus types which carry high risk for cervical cancer (high risk human papillomavirus) as assessed by a type-specific multiplex PCR. The presence of abnormal fragile histidine triad transcripts in a subset of ClN2/3 lesions with no high risk human papillomavirus suggests that this could be an independent risk factor associated with an alternative carcinogenic pathway.
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Abnormal FHITt expression profiles in cervical intraepithelial neoplastic (CIN) lesions
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Autor/in / Beteiligte Person: | TERRY, G ; HO, L ; LONDESBOROUGH, P ; CUZICK, J |
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Zeitschrift: | British journal of cancer, Jg. 86 (2002), Heft 3, S. 376-381 |
Veröffentlichung: | Basingstoke: Nature Publishing Group, 2002 |
Medientyp: | academicJournal |
Umfang: | print, 29 ref |
ISSN: | 0007-0920 (print) |
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