Combined Interstitial Laser Therapy for cancer using microwave radiometric sensor and RODEO MRI feedback. Part 1. Microwave radiometry

The concept of complex laser treatment of localized cancer is recently suggested with the focus on optimization, increasing efficiency and selectivity of Interstitial Laser Therapy (ILT) with interactive imaging and temperature feedback. This treatment is based upon a combination of ILT, photoacoustic (PA) and photodynamic therapy (PDT) with microwave radiometric remote control of the temperature in the treated zone. The features of this concept for primary breast and head and neck cancer are: 1) the application of microwave thermometry for non-invasive real-tine overheating control during ILP; 2) direct intralesional injection of a photosensitizer and dye enhancer through a tiny needle, followed by PA and ultrasonic impregnation and partly cancer cells damage; 3) combination ILT and PDT therapies; 4) post-operative PDT of the tumor by positioning LED arrays around breast; 5) using RODEO MRI for control of location of the tumor, needle and fiber and to monitor tissue changes during complex laser treatment. This paper focuses more on development of microwave radiometry temperature control. The previous experiments are presented concerning the study of remote microwave radiometric sensor for diagnostic purpose including the results of the clinical trials that have been conducted among over 1000 patients.