Lysyl oxidase activity in the cells of flexor retinaculum of individuals with carpal tunnel syndrome
In: Journal of occupational and environmental medicine, Jg. 42 (2000), Heft 6, S. 582-587
Online
academicJournal
- print, 34 ref
Zugriff:
Lysyl oxidase (LO) is produced by myofibroblast cells in some tissues and can be influenced by transforming growth factor β1 (TGFβ1). Myofibroblast-like cells are present in the flexor reticulum of patients with carpal tunnel syndrome (CTS). The goal of the current study was to determine LO activity and the effects of TGFβ1 on LO expression in the cells from patients with CTS. Tissues from both hands of five individuals with CTS were used for this study. LO activity with and without TGFβ1 stimulation was assayed in 7-day cell culture specimens. A significant difference in LO activity among individual patients, but not between right and left hands of the same patient, was observed. There was no correlation between the severity of CTS determined by nerve conduction studies and LO activity. Addition of TGFβ1 significantly increased LO in all cell lines.
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Lysyl oxidase activity in the cells of flexor retinaculum of individuals with carpal tunnel syndrome
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Autor/in / Beteiligte Person: | BOSE, K. K ; CHAKRABORTY, J ; KHUDER, S ; SMITH-MENSAH, W. H ; ROBINSON, J |
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Zeitschrift: | Journal of occupational and environmental medicine, Jg. 42 (2000), Heft 6, S. 582-587 |
Veröffentlichung: | Hagerstown, MD: Lippincott Williams & Wilkins, 2000 |
Medientyp: | academicJournal |
Umfang: | print, 34 ref |
ISSN: | 1076-2752 (print) |
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