Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice

KAWABATA, Shigetada ; KUNITOMO, Eiji ; et al.

In: Infection and immunity, Jg. 69 (2001), Heft 2, S. 924-930

Online academicJournal - print, 41 ref

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The purpose of this study was to examine the suitability of fibronectin-binding protein FBP54 as a putative vaccine for Streptococcus pyogenes infections. When the distribution of the fbp54 gene among the clinical isolates representing various M serotypes was tested by PCR and Southern blot assays, it was found that all of the strains possess this gene. Furthermore, a significant increase in immunoglobulin G (IgG) antibody titers against FBP54 was observed in sera from patients with S. pyogenes infections compared with those from healthy volunteers (P < 0.005). Mice were immunized with FBP54 subcutaneously, orally, or nasally. An enzyme-linked immunosorbent assay revealed that antigen-specific IgG antibodies were induced in the sera of immunized mice, while high salivary levels of IgA antibodies were detected after oral and nasal immunizations. Mice subcutaneously or orally immunized with FBP54 survived significantly longer following the challenge with S. pyogenes than did nonimmunized mice (P < 0.001). These results indicate that FBP54 is a promising vaccine for the prevention of S. pyogenes infections.

Titel:	Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice
Autor/in / Beteiligte Person:	KAWABATA, Shigetada ; KUNITOMO, Eiji ; TERAO, Yutaka ; NAKAGAWA, Ichiro ; KIKUCHI, Ken ; TOTSUKA, Kyo-Ichi ; HAMADA, Shigeyuki
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Infection and immunity, Jg. 69 (2001), Heft 2, S. 924-930
Veröffentlichung:	Washington, DC: American Society for Microbiology, 2001
Medientyp:	academicJournal
Umfang:	print, 41 ref
ISSN:	0019-9567 (print)
Schlagwort:	Immunology, immunopathology, allergology Immunologie, immunopathologie, allergologie Microbiology, infectious diseases Microbiologie, maladies infectieuses Parasitology Parasitologie Virology Virologie Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Microbiologie Microbiology Bactériologie Bacteriology Pouvoir pathogène, virulence, toxines, bactériocines, pyrogènes, relations hôte-bactérie, souches diverses Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Vaccins, immunsérums, immunoglobulines et anticorps monoclonaux thérapeutiques Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Bactérie Bacteria Bactériose Bacteriosis Infection Infección Mammalia Micrococcales Rodentia Streptococcaceae Vertebrata Distribution Distribución Fibronectine Fibronectin Fibronectina Gène Gene Gen Homme Human Hombre Immunisation Immunization Inmunización Liaison Binding Enlace Muqueuse Mucosa Protéine A Protein A Proteína A Protéine liaison Binding protein Proteína enlace Réponse immune Immune response Respuesta inmune Souris Mouse Ratón Streptococcie Streptococcal infection Estreptococia Streptococcus A Streptococcus pyogenes Systémique Systemic Sistémico Vaccin Vaccine Vacuna
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita-Osaka 565-0871, Japan ; Department of Infectious Diseases, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666, Japan Rights: Copyright 2002 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Microbiology

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